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BGC0000075PKS

Hygrocin A;Hygrocin B

Producing organism
Streptomyces sp. LZ35
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
PKS (Unknown)
Total steps
14
DOI
MIBiG entry
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C28H31NO8509.20 Da

Gene Cluster Map31 genes · 76,600 bp

CALKSKSKSKSKSKSKSKS20 kb76.6 kb visible · 76,600 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1Load
hgcA
+AHBA
Step 2M1
hgcA
+Methylmalonyl-CoA
Step 3M2
hgcA
+Malonyl-CoA
Step 4M3
hgcA
+Malonyl-CoA
Step 5
hgc2
Step 6M4
hgcB
+Ethylmalonyl-CoA
Step 7M5
hgcC
+Malonyl-CoA
Step 8M6
hgcD
+Methylmalonyl-CoA
Step 9M7
hgcE
+Methylmalonyl-CoA
Step 10M8
hgcE
+Malonyl-CoA
Step 11TE
hgcF
Step 12
hgc3
Step 13
hgc4
Step 14
?
+75(1)
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
175-1hgcALoading
AHBA
OC1=CC(C(O)=O)=CC(N)=C1
275-2hgcAM1
75-1;Methylmalonyl-CoA
from: 75-1
OC1=CC(/C=C(C(O)=O)\C)=CC(N)=C1
375-3hgcAM2
75-2;Malonyl-CoA
from: 75-2
OC1=CC(/C=C(C(CC(O)=O)=O)\C)=CC(N)=C1
475-4hgcAM3
75-3;Malonyl-CoA
from: 75-3
OC1=CC(/C=C(C(CC(CC(O)=O)=O)=O)\C)=CC(N)=C1
575-5hgc2
75-4
from: 75-4
O=C1C2=C(C(C(N)=C1)=O)C=C(C)C(O)=C2C(CC(O)=O)=O
675-6hgcBM4
75-5;Ethylmalonyl-CoA
from: 75-5
O=C1C2=C(C(C(N)=C1)=O)C=C(C)C(O)=C2C(CCC(C(O)=O)CC)=O
775-7hgcCM5
75-6;Malonyl-CoA
from: 75-6
O=C1C2=C(C(C(N)=C1)=O)C=C(C)C(O)=C2C(CCC(/C=C/C(O)=O)CC)=O
875-8hgcDM6
75-7;Methylmalonyl-CoA
from: 75-7
O=C1C2=C(C(C(N)=C1)=O)C=C(C)C(O)=C2C(CCC(/C=C/CC(C(O)=O)C)CC)=O
975-9hgcEM7
75-8;Methylmalonyl-CoA
from: 75-8
O=C1C2=C(C(C(N)=C1)=O)C=C(C)C(O)=C2C(CCC(/C=C/CC(C(C(C(O)=O)C)=O)C)CC)=O
1075-10hgcEM8
75-9;Malonyl-CoA
from: 75-9
O=C1C2=C(C(C(N)=C1)=O)C=C(C)C(O)=C2C(CCC(/C=C/CC(C(C(/C=C/C(O)=O)C)=O)C)CC)=O
1175-11hgcFTE
75-10
from: 75-10
O=C(CCC(CC)/C=C/C[C@H](C)C1=O)C2=C(O)C(C)=CC(C3=O)=C2C(C=C3NC(C/C=C1/C)=O)=O
1275-12hgc3
75-11
from: 75-11
O=C(CCC(CC)/C=C/C[C@@H]1C)C2=C(O)C(C)=CC(C3=O)=C2C(C=C3NC(C/C=C(C(O1)=O)/C)=O)=O
1375(1)hgc4
75-12
from: 75-12
O=C(CCC(CC)/C=C/[C@H](O)[C@@H]1C)C2=C(O)C(C)=CC(C3=O)=C2C(C=C3NC(C/C=C(C)\C(O1)=O)=O)=O
1475(2)?
75(1)
O=C(CCC(CC)/C=C/[C@H](O)[C@@H](OC1=O)C)C(C(O)=C2C)=C(C3=C2)C(C(C1(C)C=CC(N4)=O)=C4C3=O)=O
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