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BGC0000074PKS

Herbimycin A

Producing organism
Streptomyces hygroscopicus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces violaceusniger group
Biosynthetic class
PKS (Unknown)
Total steps
10
DOI
MIBiG entry
View on MIBiG ↗
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herbimycin A
C30H42N2O9574.29 Da

Gene Cluster Map30 genes · 86,941 bp

KSKSKSKSKSKSKS20 kb86.9 kb visible · 86,941 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1Load
hbmAI
+AHBA
Step 2M1
hbmAI
+Methylmalonyl-CoA
Step 3M2
hbmAI
+Methoxymalonyl-ACP
Step 4M3
hbmAI
+Methylmalonyl-CoA
Step 5M4
hbmAII
+Methylmalonyl-CoA
Step 6M5
hbmAII
+Methoxymalonyl-ACP
Step 7M6
hbmAIII
+Malonyl-CoA
Step 8M7
hbmAIII
+Methylmalonyl-CoA
Step 9
?
Step 10
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
174-1hbmAILoading
AHBA
NC1=CC(C(O)=O)=CC(O)=C1—
274-2hbmAIM1
74-1;Methylmalonyl-CoA
from: 74-1
NC1=CC(C[C@@H](C)C(O)=O)=CC(O)=C1—
374-3hbmAIM2
74-2;Methoxymalonyl-ACP
from: 74-2
NC1=CC(C[C@@H](C)CC(OC)C(O)=O)=CC(O)=C1—
474-4hbmAIM3
74-3;Methylmalonyl-CoA
from: 74-3
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)C(O)=O)=CC(O)=C1—
574-5hbmAIIM4
74-4;Methylmalonyl-CoA
from: 74-4
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/C(O)=O)=CC(O)=C1—
674-6hbmAIIM5
74-5;Methoxymalonyl-ACP
from: 74-5
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/[C@H](O)C(OC)C(O)=O)=CC(O)=C1—
774-7hbmAIIIM6
74-6;Malonyl-CoA
from: 74-6
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/[C@H](O)C(OC)CCC(O)=O)=CC(O)=C1—
874-8hbmAIIIM7
74-7;Methylmalonyl-CoA
from: 74-7
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/[C@H](O)C(OC)CC/C=C(C(O)=O)\C)=CC(O)=C1—
974-9?—
74-8
from: 74-8
O=C(/C(C)=C/CC[C@H](OC)[C@@H](O)/C(C)=C/C(C)[C@H]([C@@H](OC)C[C@@H](C1)C)O)NC2=CC1=CC(O)=C2—
1074?—
74-9
from: 74-9
O=C(/C(C)=C/CC[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/C(C)[C@H]([C@@H](OC)C[C@@H]([C@H]1OC)C)OC)NC2=CC(C=C1C2=O)=O—
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