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BGC0000073PKS

Halstoctacosanolide A

Producing organism
Streptomyces halstedii
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
22
DOI
MIBiG entry
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halstoctacosanolide A
C48H76O12844.53 Da

Gene Cluster Map9 genes · 107,687 bp

20 kb107.7 kb visible · 107,687 bp total
Biosynthetic (core)
Biosynthetic (additional)
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

22 steps · 21 edges
Step 1Load
hlsA
+Methylmalonyl-CoA
Step 2M1
hlsA
+Methylmalonyl-CoA
Step 3M2
hlsA
+Malonyl-CoA
Step 4M3
hlsB
+Malonyl-CoA
Step 5M4
hlsB
+Methylmalonyl-CoA
Step 6M5
hlsB
+Methylmalonyl-CoA
Step 7M6
hlsB
+Malonyl-CoA
Step 8M7
hlsC
+Methylmalonyl-CoA
Step 9M8
hlsC
+Malonyl-CoA
Step 10M9
hlsC
+Malonyl-CoA
Step 11M10
hlsD
+Methylmalonyl-CoA
Step 12M11
hlsD
+Malonyl-CoA
Inactive: KR
Step 13M12
hlsD
+Malonyl-CoA
Step 14M13
hlsE
+Methylmalonyl-CoA
Step 15M14
hlsE
+Malonyl-CoA
Inactive: KR
Step 16M15
hlsF
+Methylmalonyl-CoA
Step 17M16
hlsF
+Methylmalonyl-CoA
Step 18M17
hlsF
+Malonyl-CoA
Step 19M18
hlsG
+Methylmalonyl-CoA
Step 20TE
hlsG
Step 21
hlsI
Step 22
hlsH
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
173-1hlsALoading
Methylmalonyl-CoA
O=C(CC)O—
273-2hlsAM1
73-1;Methylmalonyl-CoA
from: 73-1
OC(CC)C(C)C(O)=O—
373-3hlsAM2
73-2;Malonyl-CoA
from: 73-2
OC(CC)C(C)C(O)CC(O)=O—
473-4hlsBM3
73-3;Malonyl-CoA
from: 73-3
OC(CC)C(C)C(O)CC(O)CC(O)=O—
573-5hlsBM4
73-4;Methylmalonyl-CoA
from: 73-4
OC(CC)C(C)C(O)CC(O)C/C=C(C)/C(O)=O—
673-6hlsBM5
73-5;Methylmalonyl-CoA
from: 73-5
OC(CC)C(C)C(O)CC(O)C/C=C(C)/CC(C)C(O)=O—
773-7hlsBM6
73-6;Malonyl-CoA
from: 73-6
OC(CC)C(C)C(O)CC(O)C/C=C(C)/CC(C)C(O)CC(O)=O—
873-8hlsCM7
73-7;Methylmalonyl-CoA
from: 73-7
OC(CC)C(C)C(O)CC(O)C/C=C(C)/CC(C)C(O)CC(O)C(C)C(O)=O—
973-9hlsCM8
73-8;Malonyl-CoA
from: 73-8
OC(CC)C(C)C(O)CC(O)C/C=C(C)/CC(C)C(O)CC(O)C(C)/C=C/C(O)=O—
1073-10hlsCM9
73-9;Malonyl-CoA
from: 73-9
OC(CC)C(C)C(O)CC(O)C/C=C(C)/CC(C)C(O)CC(O)C(C)/C=C/C=C/C(O)=O—
1173-11hlsDM10
73-10;Methylmalonyl-CoA
from: 73-10
OC(CC)C(C)C(O)CC(O)C/C=C(C)/CC(C)C(O)CC(O)C(C)/C=C/C=C/CC(C)C(O)=O—
1273-12hlsDM11
73-11;Malonyl-CoA
from: 73-11
OC(CC)C(C)C(O)CC(O)C/C=C(C)/CC(C)C(O)CC(O)C(C)/C=C/C=C/CC(C)C(CC(O)=O)=O{'Inactive': ['KR']}
1373-13hlsDM12
73-12;Malonyl-CoA
from: 73-12
OC(CC)C(C)C(O)CC(O)C/C=C(C)/CC(C)C(O)CC(O)C(C)/C=C/C=C/CC(C)C(CC(O)CC(O)=O)=O—
1473-14hlsEM13
73-13;Methylmalonyl-CoA
from: 73-13
OC(CC)C(C)C(O)CC(O)C/C=C(C)/CC(C)C(O)CC(O)C(C)/C=C/C=C/CC(C)C(CC(O)CCC(C)C(O)=O)=O—
1573-15hlsEM14
73-14;Malonyl-CoA
from: 73-14
OC(CC)C(C)C(O)CC(O)C/C=C(C)/CC(C)C(O)CC(O)C(C)/C=C/C=C/CC(C)C(CC(O)CCC(C)C(CC(O)=O)=O)=O{'Inactive': ['KR']}
1673-16hlsFM15
73-15;Methylmalonyl-CoA
from: 73-15
O=C(C(CCC(CC(C(C/C=C/C=C/C(C(CC(C(C/C(C)=C/CC(CC(C(C(CC)O)C)O)O)C)O)O)C)C)=O)O)C)C/C=C(C)\C(O)=O—
1773-17hlsFM16
73-16;Methylmalonyl-CoA
from: 73-16
O=C(C(CCC(CC(C(C/C=C/C=C/C(C(CC(C(C/C(C)=C/CC(CC(C(C(CC)O)C)O)O)C)O)O)C)C)=O)O)C)C/C=C(C)\C=C(C)\C(O)=O—
1873-18hlsFM17
73-17;Malonyl-CoA
from: 73-17
O=C(C(CCC(CC(C(C/C=C/C=C/C(C(CC(C(C/C(C)=C/CC(CC(C(C(CC)O)C)O)O)C)O)O)C)C)=O)O)C)C/C=C(C)\C=C(C)\C(O)CC(O)=O—
1973-19hlsGM18
73-18;Methylmalonyl-CoA
from: 73-18
O=C(C(CCC(CC(C(C/C=C/C=C/C(C(CC(C(C/C(C)=C/CC(CC(C(C(CC)O)C)O)O)C)O)O)C)C)=O)O)C)C/C=C(C)\C=C(C)\C(O)C/C=C(C)/C(O)=O—
2073-20hlsGTE
73-19
from: 73-19
CC(C/C=C/C=C/C(C(O)C1)C)C(CC2CCC(C)C(C/C=C(C)\C=C(C)\C(C/C=C(C)/C(OC1C(C)C/C(C)=C/CC(O)CC(O)C(C)C(O)CC)=O)O)(O)O2)=O—
2173-21hlsI—
73-20
from: 73-20
CC(C/C=C/C=C/C(C(O)C1)C)C(CC2CCC(C)C(C/C=C(C)\C=C(C)\C(C/C=C(C)/C(OC1C(C)C/C(C)=C/C(O)C(O)CC(O)C(C)C(O)CC)=O)O)(O)O2)=O—
2273hlsH—
73-21
from: 73-21
CC(C/C=C/C=C/C(C(O)C1)C)C(CC2CCC(C)C(C/C=C(C)\C=C(C)\C(C(/C=C(C)/C(OC1C(C)C/C(C)=C/C(O)C(O)CC(O)C(C)C(O)CC)=O)=O)O)(O)O2)=O—
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