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BGC0000066PKS

Geldanamycin

Producing organism
Streptomyces hygroscopicus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces violaceusniger group
Biosynthetic class
PKS (Unknown)
Total steps
10
DOI
MIBiG entry
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geldanamycin
C30H42N2O8558.29 Da

Gene Cluster Map23 genes · 69,644 bp

CALKSKSKSKSKSKSKS10 kb69.6 kb visible · 69,644 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1Load
gdmAI
+AHBA
Step 2M1
gdmAI
+Methylmalonyl-CoA
Step 3M2
gdmAI
+Methoxymalonyl-ACP
Step 4M3
gdmAI
+Methylmalonyl-CoA
Step 5M4
gdmAII
+Methylmalonyl-CoA
Step 6M5
gdmAII
+Methoxymalonyl-ACP
Step 7M6
gdmAIII
+Malonyl-CoA
Step 8M7
gdmAIII
+Methylmalonyl-CoA
Step 9
gdmF
Step 10
gdmN, gdmM, gdmL?, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
166-1gdmAILoading
AHBA
NC1=CC(C(O)=O)=CC(O)=C1—
266-2gdmAIM1
66-1;Methylmalonyl-CoA
from: 66-1
NC1=CC(C[C@@H](C)C(O)=O)=CC(O)=C1—
366-3gdmAIM2
66-2;Methoxymalonyl-ACP
from: 66-2
NC1=CC(C[C@@H](C)CC(OC)C(O)=O)=CC(O)=C1—
466-4gdmAIM3
66-3;Methylmalonyl-CoA
from: 66-3
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)C(O)=O)=CC(O)=C1—
566-5gdmAIIM4
66-4;Methylmalonyl-CoA
from: 66-4
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/C(O)=O)=CC(O)=C1—
666-6gdmAIIM5
66-5;Methoxymalonyl-ACP
from: 66-5
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/[C@H](O)C(OC)C(O)=O)=CC(O)=C1—
766-7gdmAIIIM6
66-6;Malonyl-CoA
from: 66-6
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/[C@H](O)C(OC)CCC(O)=O)=CC(O)=C1—
866-8gdmAIIIM7
66-7;Methylmalonyl-CoA
from: 66-7
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/[C@H](O)C(OC)CC/C=C(C(O)=O)\C)=CC(O)=C1—
966-9gdmF—
66-8
from: 66-8
O=C(/C(C)=C/CC[C@H](OC)[C@@H](O)/C(C)=C/C(C)[C@H]([C@@H](OC)C[C@@H](C1)C)O)NC2=CC1=CC(O)=C2—
1066gdmN, gdmM, gdmL?, ?—
66-9
from: 66-9
O=C(/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/C(C)[C@H]([C@@H](OC)C[C@@H](C1)C)O)NC2=CC(O)C(OC)=C1C2=O—
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