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BGC0000059PKS

Filipin

Producing organism
Streptomyces avermitilis MA-4680 = NBRC 14893
Taxonomy
Bacteria›Actinobacteria›Streptomycetales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
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filipin
C35H58O11654.40 Da

Gene Cluster Map13 genes · 80,370 bp

KSKSKSKSKSKSKSKSKSKSKSKSKSKS20 kb80.4 kb visible · 80,370 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1Load
SAV_419
+Malonyl-CoA
Step 2M1
SAV_419
+Malonyl-CoA
Step 3M2
SAV_419
+Malonyl-CoA
Step 4M3
SAV_419
+Malonyl-CoA
Step 5M4
SAV_419
+Malonyl-CoA
Step 6M5
SAV_418
+Malonyl-CoA
Step 7M6
SAV_418
+Methylmalonyl-CoA
Step 8M7
SAV_417
+Malonyl-CoA
Inactive: DH
Step 9M8
SAV_416
+Malonyl-CoA
Step 10M9
SAV_416
+Malonyl-CoA
Step 11M10
SAV_416
+Malonyl-CoA
Step 12M11
SAV_416
+Malonyl-CoA
Step 13M12
SAV_415
+Malonyl-CoA
Step 14M13
SAV_415
+Hexylmalonyl-CoA
Step 15TE
SAV_415
Step 16
SAV_412
Step 17
SAV_413
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
159-1SAV_419Loading
Malonyl-CoA
O=C(C)O—
259-2SAV_419M1
59-1;Malonyl-CoA
from: 59-1
O[C@H](C)CC(O)=O—
359-3SAV_419M2
59-2;Malonyl-CoA
from: 59-2
O[C@H](C)C/C=C/C(O)=O—
459-4SAV_419M3
59-3;Malonyl-CoA
from: 59-3
O[C@H](C)C/C=C/C=C/C(O)=O—
559-5SAV_419M4
59-4;Malonyl-CoA
from: 59-4
O[C@H](C)C/C=C/C=C/C=C/C(O)=O—
659-6SAV_418M5
59-5;Malonyl-CoA
from: 59-5
O[C@H](C)C/C=C/C=C/C=C/C=C/C(O)=O—
759-7SAV_418M6
59-6;Methylmalonyl-CoA
from: 59-6
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/C(O)=O—
859-8SAV_417M7
59-7;Malonyl-CoA
from: 59-7
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)CC(O)=O{'Inactive': ['DH']}
959-9SAV_416M8
59-8;Malonyl-CoA
from: 59-8
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)CC(O)=O—
1059-10SAV_416M9
59-9;Malonyl-CoA
from: 59-9
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
1159-11SAV_416M10
59-10;Malonyl-CoA
from: 59-10
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
1259-12SAV_416M11
59-11;Malonyl-CoA
from: 59-11
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
1359-13SAV_415M12
59-12;Malonyl-CoA
from: 59-12
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
1459-14SAV_415M13
59-13;Hexylmalonyl-CoA
from: 59-13
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C(C(O)=O)CCCCCC—
1559-15SAV_415TE
59-14
from: 59-14
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/C[C@@H](C)OC(C1CCCCCC)=O—
1659-16SAV_412—
59-15
from: 59-15
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC(C1CCCCCC)=O—
1759SAV_413—
59-16
from: 59-16
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC(C1[C@H](O)CCCCC)=O—
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