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BGC0000058PKS

FD-891

Producing organism
Streptomyces graminofaciens
Taxonomy
Bacteria›Actinobacteria›Streptomycetales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
17
DOI
MIBiG entry
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FD-891
C33H54O8578.38 Da

Gene Cluster Map8 genes · 74,321 bp

KSKSKSKSKSKSKSKSKSKSKSKSKS10 kb74.3 kb visible · 74,321 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1Load
gfsA
+Malonyl-CoA
Step 2M1
gfsA
+Methylmalonyl-CoA
Step 3M2
gfsA
+Methylmalonyl-CoA
Step 4M3
gfsA
+Malonyl-CoA
Step 5M4
gfsA
+Malonyl-CoA
Step 6M5
gfsB
+Methylmalonyl-CoA
Step 7M6
gfsB
+Malonyl-CoA
Step 8M7
gfsB
+Malonyl-CoA
Step 9M8
gfsC
+Malonyl-CoA
Step 10M9
gfsD
+Malonyl-CoA
Step 11M10
gfsD
+Methylmalonyl-CoA
Inactive: DH
Step 12M11
gfsE
+Methylmalonyl-CoA
Step 13M12
gfsE
+Methylmalonyl-CoA
Step 14TE
gfsE
Step 15
gfsG
Step 16
gfsF
Step 17
gfsF
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
158-1gfsALoading
Malonyl-CoA
O=C(O)C—
258-2gfsAM1
58-1;Methylmalonyl-CoA
from: 58-1
O[C@H]([C@@H](C)C(O)=C)C—
358-3gfsAM2
58-2;Methylmalonyl-CoA
from: 58-2
O[C@H]([C@@H](C)[C@H](O)[C@H](C)C(O)=O)C—
458-4gfsAM3
58-3;Malonyl-CoA
from: 58-3
O[C@H]([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)CC(O)=O)C—
558-5gfsAM4
58-4;Malonyl-CoA
from: 58-4
O[C@H]([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C(O)=O)C—
658-6gfsBM5
58-5;Methylmalonyl-CoA
from: 58-5
O[C@H]([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@@H](C(O)=O)C)C—
758-7gfsBM6
58-6;Malonyl-CoA
from: 58-6
O[C@H]([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@@H]([C@@H](O)CC(O)=C)C)C—
858-8gfsBM7
58-7;Malonyl-CoA
from: 58-7
O[C@H]([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@@H]([C@@H](O)C/C=C/C(O)=O)C)C—
958-9gfsCM8
58-8;Malonyl-CoA
from: 58-8
O[C@H]([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@@H]([C@@H](O)C/C=C/CCC(O)=O)C)C—
1058-10gfsDM9
58-9;Malonyl-CoA
from: 58-9
O[C@H]([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@@H]([C@@H](O)C/C=C/CC/C=C/C(O)=O)C)C—
1158-11gfsDM10
58-10;Methylmalonyl-CoA
from: 58-10
O[C@H]([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@@H]([C@@H](O)C/C=C/CC/C=C/[C@@H](O)[C@@H](C(O)=O)C)C)C{'Inactive': ['DH']}
1258-12gfsEM11
58-11;Methylmalonyl-CoA
from: 58-11
O[C@H]([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@@H]([C@@H](O)C/C=C/CC/C=C/[C@@H](O)[C@@H](/C=C(C(O)=O)\C)C)C)C—
1358-13gfsEM12
58-12;Methylmalonyl-CoA
from: 58-12
O[C@H]([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@@H]([C@@H](O)C/C=C/CC/C=C/[C@@H](O)[C@@H](/C=C(/C=C(C(O)=O)\C)C)C)C)C—
1458-14gfsETE
58-13
from: 58-13
C[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@H](C)[C@@H](OC1=O)C/C=C/CC/C=C/[C@@H](O)[C@H](C)/C=C(/C=C1\C)C—
1558-15gfsG—
58-14
from: 58-14
C[C@H](OC)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@H](C)[C@@H](OC1=O)C/C=C/CC/C=C/[C@@H](O)C(C)/C=C(/C=C1\C)C—
1658-16gfsF—
58-15
from: 58-15
C[C@H](OC)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@H](C)[C@@H](OC1=O)C/C=C/CC[C@H]2[C@@H](O2)[C@@H](O)[C@H](C)/C=C(/C=C1\C)C—
1758gfsF—
58-16
from: 58-16
C[C@H](OC)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@H](C)[C@@H](OC1=O)C/C=C/C[C@@H](O)[C@H]2[C@@H](O2)[C@@H](O)[C@H](C)/C=C(/C=C1\C)C—
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