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BGC0000055PKS

Erythromycin A;Erythromycin B:Erythromycin C;Erythromycin D

Producing organism
Saccharopolyspora erythraea NRRL 2338
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Saccharopolyspora
Biosynthetic class
PKS (Type I)
Total steps
27
DOI
MIBiG entry
View on MIBiG ↗
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C37H67NO13733.46 Da

Gene Cluster Map23 genes · 54,612 bp

ATKSATKSATKSATKSATERKSATKSATMT10 kb54.6 kb visible · 54,612 bp total
Biosynthetic (core)
Biosynthetic (additional)
Resistance
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
MTMethyltransferase
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

27 steps · 25 edges
Step 1Load
SACE_0721
+Propionyl-CoA
Step 10
Start
+4,6-dideoxy-4-oxo…
Step 27
SACE_0713/SACE_0728
+55(2)/55(3)
Step 2M1
SACE_0721
+Methylmalonyl-CoA
Step 11
SACE_0717
Step 12
SACE_0717
Step 14
SACE_0714
Step 19
SACE_0725
Step 3M2
SACE_0721
+Methylmalonyl-CoA
Step 13
SACE_0727?
Step 15
?/SACE_0714
Step 20
SACE_0734/SACE_0716?
Step 4M3
SACE_0723
+Methylmalonyl-CoA
Inactive: KR
Step 16
SACE_0731
Step 21
SACE_0716/SACE_0734?
Step 5M4
SACE_0723
+Methylmalonyl-CoA
Step 17
SACE_0720
Step 18
SACE_0720
Step 22
SACE_0718
Step 6M5
SACE_0724
+Methylmalonyl-CoA
Step 7M6
SACE_0724
+Methylmalonyl-CoA
Step 8TE
SACE_0724
Step 9
SACE_0730
Step 23
SACE_0719
+(55-17/55-18)
Step 24
SACE_0726
Step 25
SACE_0728
+55(1)
Step 26
SACE_0713
+55(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions27 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
155-1SACE_0721Loading
Propionyl-CoA
CCC(O)=O—
255-2SACE_0721M1
55-1;Methylmalonyl-CoA
from: 55-1
C[C@@H]([C@H](O)CC)C(O)=O—
355-3SACE_0721M2
55-2;Methylmalonyl-CoA
from: 55-2
C[C@@H]([C@H](O)CC)C(O)C(C)C(O)=O—
455-4SACE_0723M3
55-3;Methylmalonyl-CoA
from: 55-3
C[C@@H]([C@H](O)CC)C(O)C(C)C([C@H](C)C(O)=O)=O{'Inactive':['KR']}
555-5SACE_0723M4
55-4;Methylmalonyl-CoA
from: 55-4
C[C@@H]([C@H](O)CC)C(O)C(C)C([C@H](C)C[C@H](C)C(O)=O)=O—
655-6SACE_0724M5
55-5;Methylmalonyl-CoA
from: 55-5
C[C@@H]([C@H](O)CC)C(O)C(C)C([C@H](C)C[C@H](C)C(O)C(C)C(O)=O)=O—
755-7SACE_0724M6
55-6;Methylmalonyl-CoA
from: 55-6
C[C@@H]([C@H](O)CC)C(O)C(C)C([C@H](C)C[C@H](C)C(O)C(C)C(O)C(C)C(O)=O)=O—
855-8SACE_0724TE
55-7
from: 55-7
O[C@@H]1[C@@H](C)[C@H](O)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@@H]1C)=O)=O—
955-9SACE_0730—
55-8
from: 55-8
O[C@@H]1[C@@H](C)[C@H](O)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]1(O)C)=O)=O—
1055-10Start—
4,6-dideoxy-4-oxo-dTDP-D-glucose
O[C@H]([C@@H](O)C(O[R])O[C@@H]1C)C1=O—
1155-11SACE_0717—
55-10
from: 55-10
OC1=CC(O[R])O[C@H](C)C1=O—
1255-12SACE_0717—
55-10
from: 55-10
O=C(CC(O[R])O[C@@H]1C)C1=O—
1355-13SACE_0727?—
55-11/55-12
from: 55-11/55-12
O=C1[C@@H](O)CC(O[R])O[C@@H]1C—
1455-14SACE_0714—
55-10
from: 55-10
O=C1[C@H]([C@@H](O)C(O[R])O[C@H]1C)O—
1555-15?/SACE_0714—
55-13/55-14
from: 55-13/55-14
O=C1[C@H](CC(O[R])O[C@H]1C)O—
1655-16SACE_0731—
55-15
from: 55-15
O=C1[C@@](CC(O[R])O[C@H]1C)(O)C—
1755-17SACE_0720—
55-16
from: 55-16
[R]OC1C[C@](O)(C)[C@@H](O)[C@H](C)O1—
1855-18SACE_0720—
55-16
from: 55-16
O[C@@](C1)(C)[C@@H](O)[C@H](C)OC1O[R]—
1955-19SACE_0725—
55-10
from: 55-10
O[C@@H]1C([C@H](O)[C@@H](C)OC1O[R])=O—
2055-20SACE_0734/SACE_0716?—
55-19
from: 55-19
O[C@@H]1C(C[C@@H](C)OC1O[R])=O—
2155-21SACE_0716/SACE_0734?—
55-20
from: 55-20
O[C@@H]1[C@@H](N)C[C@@H](C)OC1O[R]—
2255-22SACE_0718—
55-21
from: 55-21
O[C@@H]1[C@@H](N(C)C)C[C@@H](C)OC1O[R]—
2355-23SACE_0719—
55-9;(55-17/55-18)
from: 55-9
O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@@](O)(C)C2)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]1(O)C)=O)=O—
2455(1)SACE_0726—
55-22;55-23
from: 55-22, 55-23
O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](O)(C)C3)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]2(O)C)=O)=O)O[C@H](C)C[C@@H]1N(C)C—
2555(2)SACE_0728—
55(1)
O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](OC)(C)C3)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]2(O)C)=O)=O)O[C@H](C)C[C@@H]1N(C)C—
2655(3)SACE_0713—
55(1)
O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](O)(C)C3)[C@@H](C)C(O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]2(O)C)=O)=O)O[C@H](C)C[C@@H]1N(C)C—
2755(4)SACE_0713/SACE_0728—
55(2)/55(3)
O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](OC)(C)C3)[C@@H](C)C(O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]2(O)C)=O)=O)O[C@H](C)C[C@@H]1N(C)C—
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