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BGC0000054PKS

Erythromycin

Producing organism
Aeromicrobium erythreum
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Propionibacteriales›Nocardioidaceae›Aeromicrobium
Biosynthetic class
PKS (Unknown)
Total steps
27
DOI
MIBiG entry
—
Loading…
erythromycin
C37H67NO13733.46 Da

Pathway Graphsteps arranged in biosynthetic order

27 steps · 26 edges
Step 1Load
eryAI
+Propionyl-CoA
Step 10
Start
+4,6-dideoxy-4-oxo…
Step 2M1
eryAI
+Methylmalonyl-CoA
Step 11
eryBVI
Step 12
eryBVI
Step 14
eryBVII
Step 19
eryCII
Step 3M2
eryAI
+Methylmalonyl-CoA
Step 13
eryBII?
Step 15
?/eryBVII
Step 20
eryCI/eryCIV?
Step 4M3
eryAII
+Methylmalonyl-CoA
Step 16
eryBIII
Step 21
eryCIV/eryCI?
Step 5M4
eryAII
+Methylmalonyl-CoA
Step 17
eryBIV
Step 18
eryBIV
Step 22
eryCVI
Step 6M5
eryAIII
+Methylmalonyl-CoA
Step 7M6
eryAIII
+Methylmalonyl-CoA
Step 8TE
eryAIII
Step 9
eryF
Step 23
eryBV
+(54-17/54-18)
Step 24
eryCIII
Step 25
eryG
Step 26
eryK
Step 27
eryK/eryG
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions27 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
154-1eryAILoading
Propionyl-CoA
CCC(O)=O—
254-2eryAIM1
54-1;Methylmalonyl-CoA
from: 54-1
C[C@@H]([C@H](O)CC)C(O)=O—
354-3eryAIM2
54-2;Methylmalonyl-CoA
from: 54-2
C[C@@H]([C@H](O)CC)C(O)C(C)C(O)=O—
454-4eryAIIM3
54-3;Methylmalonyl-CoA
from: 54-3
C[C@@H]([C@H](O)CC)C(O)C(C)C([C@H](C)C(O)=O)=O—
554-5eryAIIM4
54-4;Methylmalonyl-CoA
from: 54-4
C[C@@H]([C@H](O)CC)C(O)C(C)C([C@H](C)C[C@H](C)C(O)=O)=O—
654-6eryAIIIM5
54-5;Methylmalonyl-CoA
from: 54-5
C[C@@H]([C@H](O)CC)C(O)C(C)C([C@H](C)C[C@H](C)C(O)C(C)C(O)=O)=O—
754-7eryAIIIM6
54-6;Methylmalonyl-CoA
from: 54-6
C[C@@H]([C@H](O)CC)C(O)C(C)C([C@H](C)C[C@H](C)C(O)C(C)C(O)C(C)C(O)=O)=O—
854-8eryAIIITE
54-7
from: 54-7
O[C@@H]1[C@@H](C)[C@H](O)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@@H]1C)=O)=O—
954-9eryF—
54-8
from: 54-8
O[C@@H]1[C@@H](C)[C@H](O)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]1(O)C)=O)=O—
1054-10Start—
4,6-dideoxy-4-oxo-dTDP-D-glucose
O[C@H]([C@@H](O)C(O[R])O[C@@H]1C)C1=O—
1154-11eryBVI—
54-10
from: 54-10
OC1=CC(O[R])O[C@H](C)C1=O—
1254-12eryBVI—
54-10
from: 54-10
O=C(CC(O[R])O[C@@H]1C)C1=O—
1354-13eryBII?—
54-11/54-12
from: 54-11/54-12
O=C1[C@@H](O)CC(O[R])O[C@@H]1C—
1454-14eryBVII—
54-10
from: 54-10
O=C1[C@H]([C@@H](O)C(O[R])O[C@H]1C)O—
1554-15?/eryBVII—
54-13/54-14
from: 54-13/54-14
O=C1[C@H](CC(O[R])O[C@H]1C)O—
1654-16eryBIII—
54-15
from: 54-15
O=C1[C@@](CC(O[R])O[C@H]1C)(O)C—
1754-17eryBIV—
54-16
from: 54-16
[R]OC1C[C@](O)(C)[C@@H](O)[C@H](C)O1—
1854-18eryBIV—
54-16
from: 54-16
O[C@@](C1)(C)[C@@H](O)[C@H](C)OC1O[R]—
1954-19eryCII—
54-10
from: 54-10
O[C@@H]1C([C@H](O)[C@@H](C)OC1O[R])=O—
2054-20eryCI/eryCIV?—
54-19
from: 54-19
O[C@@H]1C(C[C@@H](C)OC1O[R])=O—
2154-21eryCIV/eryCI?—
54-20
from: 54-20
O[C@@H]1[C@@H](N)C[C@@H](C)OC1O[R]—
2254-22eryCVI—
54-21
from: 54-21
O[C@@H]1[C@@H](N(C)C)C[C@@H](C)OC1O[R]—
2354-23eryBV—
54-9;(54-17/54-18)
from: 54-9
O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@@](O)(C)C2)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]1(O)C)=O)=O—
2454-24eryCIII—
54-22;54-23
from: 54-22, 54-23
O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](O)(C)C3)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]2(O)C)=O)=O)O[C@H](C)C[C@@H]1N(C)C—
2554-25eryG—
54-24
from: 54-24
O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](OC)(C)C3)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]2(O)C)=O)=O)O[C@H](C)C[C@@H]1N(C)C—
2654-26eryK—
54-24
from: 54-24
O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](O)(C)C3)[C@@H](C)C(O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]2(O)C)=O)=O)O[C@H](C)C[C@@H]1N(C)C—
2754eryK/eryG—
54-25/54-26
from: 54-25/54-26
O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](OC)(C)C3)[C@@H](C)C(O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)C([C@H](C)C[C@]2(O)C)=O)=O)O[C@H](C)C[C@@H]1N(C)C—
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