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BGC0000052PKS

ECO-02301

Producing organism
Streptomyces aizunensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
38
DOI
MIBiG entry
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ECO-02301
C70H108N2O201296.75 Da

Gene Cluster Map28 genes · 161,719 bp

20 kb161.7 kb visible · 161,719 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

38 steps · 37 edges
Step 1
Start
Step 32
Start
Step 33
Start
Step 37
Start
+L-rhamnose
Step 2
AAX98202.1
Step 34
AAX98209.1
Step 3
AAX98201.1
Step 35
AAX98210.1
Step 4
AAX98207.1
Step 36
?
Step 5Load
AAX98193.1;AAX98184.1
Step 6M1
AAX98184.1
+Malonyl-CoA
Step 7M2
AAX98184.1
+Malonyl-CoA
Step 8M3
AAX98184.1
+Malonyl-CoA
Step 9M4
AAX98184.1
+Malonyl-CoA
Step 10M5
AAX98184.1
+Malonyl-CoA
Step 11M6
AAX98185.1
+Malonyl-CoA
Step 12M7
AAX98185.1
+Malonyl-CoA
Step 13M8
AAX98186.1
+Malonyl-CoA
Step 14M9
AAX98186.1
+Malonyl-CoA
Step 15M10
AAX98186.1
+Malonyl-CoA
Step 16M11
AAX98186.1
+Malonyl-CoA
Step 17M12
AAX98187.1
+Methylmalonyl-CoA
Step 18M13
AAX98188.1
+Malonyl-CoA
Step 19M14
AAX98188.1
+Malonyl-CoA
Step 20M15
AAX98188.1
+Malonyl-CoA
Step 21M16
AAX98189.1
+Malonyl-CoA
Step 22M17
AAX98189.1
+Malonyl-CoA
Step 23M18
AAX98189.1
+Malonyl-CoA
Step 24M19
AAX98190.1
+Methylmalonyl-CoA
Step 25M20
AAX98190.1
+Methylmalonyl-CoA
Step 26M21
AAX98191.1
+Malonyl-CoA
Step 27M22
AAX98191.1
+Malonyl-CoA
Step 28M23
AAX98191.1
+Malonyl-CoA
Step 29M24
AAX98191.1
+Malonyl-CoA
Step 30M25
AAX98192.1
+Malonyl-CoA
Step 31M26
AAX98192.1
+Malonyl-CoA
Step 38
AAX98208.1, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions38 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
152-1Start—
N=C(NCCCC(N)C(O)=O)N—
252-2AAX98202.1—
52-1
from: 52-1
N=C(NCCCC(C(O)=O)=O)N—
352-3AAX98201.1—
52-2
from: 52-2
N=C(NCCCC([R])=O)N—
452-4AAX98207.1—
52-3
from: 52-3
NCCCC([R])=O—
552-5AAX98193.1;AAX98184.1Loading
52-4
from: 52-4
NCCCC(O)=O—
652-6AAX98184.1M1
52-5;Malonyl-CoA
from: 52-5
NCCCC(O)CC(O)=O—
752-7AAX98184.1M2
52-6;Malonyl-CoA
from: 52-6
NCCCC(O)CC(O)CC(O)=O—
852-8AAX98184.1M3
52-7;Malonyl-CoA
from: 52-7
NCCCC(O)CC(O)C/C=C/C(O)=O—
952-9AAX98184.1M4
52-8;Malonyl-CoA
from: 52-8
NCCCC(O)CC(O)C/C=C/C(O)CC(O)=O—
1052-10AAX98184.1M5
52-9;Malonyl-CoA
from: 52-9
NCCCC(O)CC(O)C/C=C/C(O)CC(O)CC(O)=O—
1152-11AAX98185.1M6
52-10;Malonyl-CoA
from: 52-10
NCCCC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(O)=O—
1252-12AAX98185.1M7
52-11;Malonyl-CoA
from: 52-11
NCCCC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(O)CC(O)=O—
1352-13AAX98186.1M8
52-12;Malonyl-CoA
from: 52-12
NCCCC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(O)C/C=C/C(O)=O—
1452-14AAX98186.1M9
52-13;Malonyl-CoA
from: 52-13
NCCCC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)=O—
1552-15AAX98186.1M10
52-14;Malonyl-CoA
from: 52-14
NCCCC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)=O—
1652-16AAX98186.1M11
52-15;Malonyl-CoA
from: 52-15
NCCCC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(O)=O—
1752-17AAX98187.1M12
52-16;Methylmalonyl-CoA
from: 52-16
NCCCC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)=O)=O—
1852-18AAX98188.1M13
52-17;Malonyl-CoA
from: 52-17
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)CC(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
1952-19AAX98188.1M14
52-18;Malonyl-CoA
from: 52-18
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
2052-20AAX98188.1M15
52-19;Malonyl-CoA
from: 52-19
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
2152-21AAX98189.1M16
52-20;Malonyl-CoA
from: 52-20
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
2252-22AAX98189.1M17
52-21;Malonyl-CoA
from: 52-21
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C=C/C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
2352-23AAX98189.1M18
52-22;Malonyl-CoA
from: 52-22
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
2452-24AAX98190.1M19
52-23;Methylmalonyl-CoA
from: 52-23
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
2552-25AAX98190.1M20
52-24;Methylmalonyl-CoA
from: 52-24
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
2652-26AAX98191.1M21
52-25;Malonyl-CoA
from: 52-25
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
2752-27AAX98191.1M22
52-26;Malonyl-CoA
from: 52-26
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CCC(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
2852-28AAX98191.1M23
52-27;Malonyl-CoA
from: 52-27
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
2952-29AAX98191.1M24
52-28;Malonyl-CoA
from: 52-28
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
3052-30AAX98192.1M25
52-29;Malonyl-CoA
from: 52-29
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
3152-31AAX98192.1M26
52-30;Malonyl-CoA
from: 52-30
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C=C/C(O)=O)C)=O)O)O)O)O)O)O)O)O)O—
3252-32Start—
O=C(CN)O—
3352-33Start—
O=C(CCC(O)=O)[R]—
3452-34AAX98209.1—
52-32;52-33
from: 52-32, 52-33
O=C(CCC(O)=O)CN—
3552-35AAX98210.1—
52-34
from: 52-34
O=C(CCC([R])=O)CN—
3652-36?—
52-35
from: 52-35
OC(CC1)=C(N)C1=O—
3752-37Start—
L-rhamnose
CC1OC(O)C(O)C(O)C1O—
3852AAX98208.1, ?—
52-31;52-36;52-37
from: 52-31, 52-36, 52-37
NCCCC(CC(C/C=C/C(CC(CC(CC(C/C=C/C(CC(CC(CC(C(C(OC1OC(C)C(O)C(O)C1O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C=C/C(NC2=C(O)CCC2=O)=O)C)=O)O)O)O)O)O)O)O)O)O—
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