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BGC0000051PKS

Ebelactone A;Ebelactone B

Producing organism
Kitasatospora aburaviensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Kitasatospora
Biosynthetic class
PKS (Unknown)
Total steps
9
DOI
MIBiG entry
View on MIBiG ↗
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C20H34O4338.25 Da

Gene Cluster Map10 genes · 37,060 bp

KSATKSATERKRKSATKRKSKSATERKRKSATKRKSA5 kb37.1 kb visible · 37,060 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

9 steps · 8 edges
Step 1M1
ebeA
+Malonyl-CoA
Step 2M2
ebeB
+Methylmalonyl-CoA
Step 3M3
ebeC
+Methylmalonyl-CoA
Step 4M4
ebeD;ebeE;ebeF
Iterative
Step 5M5
ebeF
+Methylmalonyl-CoA
Step 6(1)M6
ebeG
+Methylmalonyl-CoA
Step 6(2)M6
ebeG
+Ethylmalonyl-CoA
Step 7(1)
?
Step 7(2)
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
151-1ebeAM1
Malonyl-CoA
O=C(C)O—
251-2ebeBM2
51-1;Methylmalonyl-CoA
from: 51-1
CC[C@@H](C)C(O)=O—
351-3ebeCM3
51-2;Methylmalonyl-CoA
from: 51-2
CC[C@@H](C)[C@@H](O)[C@H](C)C(O)=O—
451-4ebeD;ebeE;ebeFM4
51-3
from: 51-3
CC[C@@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C(O)=O)=O{'Iteration': [([None], 'Met…
551-5ebeFM5
51-4;Methylmalonyl-CoA
from: 51-4
CC[C@@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C[C@H](C)C(O)=O)=O—
6(1)51-6ebeGM6
51-5;Methylmalonyl-CoA
from: 51-5
CC[C@@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)C(O)=O)=O—
6(2)51-7ebeGM6
51-5;Ethylmalonyl-CoA
from: 51-5
CC[C@@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C[C@H](C)[C@H](O)[C@H](CC)C(O)=O)=O—
7(1)51(1)?—
51-6
from: 51-6
CC[C@@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C[C@@H]([C@@H]1OC([C@H]1C)=O)C)=O—
7(2)51(2)?—
51-7
from: 51-7
CC[C@@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C[C@@H]([C@@H]1OC([C@H]1CC)=O)C)=O—
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