NPdia

BGC0000050PKS

E-837

Producing organism: Streptomyces aculeolatus
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS(Unknown)
Total steps: 14
DOI: 10.1038/ja.2006.24
MIBiG entry: View on MIBiG ↗

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E-837

C₂₂H₃₄O₅378.24 Da

Biosynthetic (core)

Biosynthetic (additional)

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Thioesterase (TE)

Docking N-term

Docking C-term

14 steps · 13 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`50-1`	ABB88519.1	M1	Malonyl-CoA	`O=C(O)CC`	—
2	`50-2`	ABB88519.1	M2	50-1;Methylmalonyl-CoA from: 50-1	`C/C=C(C)/C(O)=O`	—
3	`50-3`	ABB88519.1	M3	50-2;Methylmalonyl-CoA from: 50-2	`C/C=C(C)/C(O)C(C)C(O)=O`	—
4	`50-4`	ABB88520.1	M4	50-3;Malonyl-CoA from: 50-3	`C/C=C(C)/C(O)C(C)/C=C/C(O)=O`	—
5	`50-5`	ABB88520.1	M5	50-4;Methylmalonyl-CoA from: 50-4	`C/C=C(C)/C(O)C(C)/C=C/C=C(C)/C(O)=O`	—
6	`50-6`	ABB88521.1	M6	50-5;Malonyl-CoA from: 50-5	`C/C=C(C)/C(O)C(C)/C=C/C=C(C)/CCC(O)=O`	—
7	`50-7`	ABB88522.1	M7	50-6;Malonyl-CoA from: 50-6	`C/C=C(C)/C(O)C(C)/C=C/C=C(C)/CCC(O)CC(O)=O`	{'Inactive': ['DH']}
8	`50-8`	ABB88522.1	M8	50-7;Methylmalonyl-CoA from: 50-7	`C/C=C(C)/C(O)C(C)/C=C/C=C(C)/CCC(O)CC(C(C)C(O)=O)=O`	{'Inactive': ['KR']}
9	`50-9`	ABB88523.1	M9	50-8;Methylmalonyl-CoA from: 50-8	`C/C=C(C)/C(O)C(C)/C=C/C=C(C)/CCC(O)CC(C(C)C(C(C(O)=O)C)=O)=O`	—
10	`50-10`	ABB88523.1	TE	50-9 from: 50-9	`OC(CCC)CC(OC1=O)=C(C)C(C1C)=O`	—
11	`50-11`	ABB88517.1;ABB88518.1	—	50-10 from: 50-10	`OC(CCC)CC(OC1=O)=C(C)C(C1(C)O)=O`	—
12	`50-12`	ABB88524.1	—	50-11 from: 50-11	`CC(C(C(O)(C)O1)=O)=C(CC(CCC)O)OC1=O`	—
13	`50-13`	?	—	50-12 from: 50-12	`O=C(C)C(/C(C)=C(CC(CCC)O)\O)=O`	—
14	`50`	?	—	50-13 from: 50-13	`C/C=C(C)/C(O)C(C)/C=C/C=C(C)/CCC(O)CC1=C(C)C(C(C)(O)O1)=O`	—

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