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BGC0000047PKS

10,11-dihydro-8-deoxy-12,13-deepoxy-12,13-dihydrochalcomycin

Producing organism
Streptomyces sp. KCTC 0041BP
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
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10,11-dihydro-8-deoxy-12,13-deepoxy-12,13-dihydrochalcomycin
C34H58O12658.39 Da

Gene Cluster Map31 genes · 75,439 bp

KSKSKSKSKSKSKSKS20 kb75.4 kb visible · 75,439 bp total
Biosynthetic (core)
Biosynthetic (additional)
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

16 steps · 16 edges
Step 1Load
gerSI
+Malonyl-CoA
Step 10
Start
+Glucose-1-phospha…
Step 2M1
gerSI
+Methylmalonyl-CoA
Step 11
gerD
Step 3M2
gerSI
+Malonyl-CoA
Step 12
gerE
Step 4M3
gerSII
+Malonyl-CoA
Step 13
gerF
Step 5M4
gerSIII
+Methylmalonyl-CoA
Step 14
gerKI
Step 6M5
gerSIII
+Methylmalonyl-CoA
Step 7M6
gerSIV
+Methylmalonyl-CoA
Step 8M7
gerSV
+Malonyl-CoA
Step 9TE
gerSV
Step 15
(gerB/gerN, gerKII), (g…
Step 16
gerTI, gerPIII
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
147-1gerSILoading
Malonyl-CoA
O=C(O)C—
247-2gerSIM1
47-1;Methylmalonyl-CoA
from: 47-1
C[C@@H](O)[C@@H](C)C(O)=O—
347-3gerSIM2
47-2;Malonyl-CoA
from: 47-2
C[C@@H](O)[C@@H](C)/C=C/C(O)=O—
447-4gerSIIM3
47-3;Malonyl-CoA
from: 47-3
C[C@@H](O)[C@@H](C)/C=C/C=C/C(O)=O—
547-5gerSIIIM4
47-4;Methylmalonyl-CoA
from: 47-4
C[C@@H](O)[C@@H](C)/C=C/C=C/C([C@H](C)C(O)=O)=O—
647-6gerSIIIM5
47-5;Methylmalonyl-CoA
from: 47-5
C[C@@H](O)[C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)C(O)=O)=O—
747-7gerSIVM6
47-6;Methylmalonyl-CoA
from: 47-6
C[C@@H](O)[C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)[C@H](O)[C@@H](C)C(O)=O)=O—
847-8gerSVM7
47-7;Malonyl-CoA
from: 47-7
C[C@@H](O)[C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)[C@H](O)[C@@H](C)C(CC(O)=O)=O)=O—
947-9gerSVTE
47-8
from: 47-8
O=C1CC(O[C@H](C)[C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)C(O)[C@H]1C)=O)=O—
1047-10Start—
Glucose-1-phosphate
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
1147-11gerD—
47-10
from: 47-10
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
1247-12gerE—
47-11
from: 47-11
O[C@H]([C@@H](O)[C@@H]([R])O[C@@H]1C)C1=O—
1347-13gerF—
47-12
from: 47-12
C[C@H]1O[C@H]([R])[C@H](O)[C@H](O)C1=O—
1447-14gerKI—
47-13
from: 47-13
C[C@H]1O[C@H]([R])[C@H](O)[C@H](O)[C@@H]1O—
1547-15(gerB/gerN, gerKII), (gerTII, gerMI)—
47-9;47-12
from: 47-9, 47-12
O=C1CC(O[C@H](C)[C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)[C@H](O[C@@H]2[C@H](O)[C@@H](OC)C[C@@H](C)O2)[C@H]1C)=O)=O—
1647gerTI, gerPIII—
47-14;47-15
from: 47-14, 47-15
O=C1CC(O[C@H](C)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O)[C@@H](C)O2)/C=C/C=C/C([C@H](C)C[C@H](C)[C@H](O[C@@H]3[C@H](O)[C@@H](OC)C[C@@H](C)O3)[C@H]1C)=O)=O—
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