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BGC0000042PKS

Cremimycin

Producing organism
Streptomyces sp. MJ635-86F5
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
PKS (Unknown)
Total steps
32
DOI
MIBiG entry
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cremimycin
C35H53NO9631.37 Da

Gene Cluster Map40 genes · 105,855 bp

20 kb105.9 kb visible · 105,855 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ACPSACP synthase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

32 steps · 31 edges
Step 1Load
cmiP4
+Methylmalonyl-CoA
Step 5
Start
+Glycine
Step 9
Start
+L-amino acid
Step 24
Start
+D-glucose-1-phosp…
Step 2M1
cmiP4
+Malonyl-CoA
Step 25
cmiC7
Step 3M2
cmiP4
+Malonyl-CoA
Step 26
cmiC6
Step 4M3
cmiP3;cmiP2
+Malonyl-CoA
Step 27
cmiC5
Step 6
cmiS1
Step 28
cmiC4
Step 7
cmiS2
Step 29
cmiC3
Step 8
cmiS6;cmiS4
Step 30
cmiC2
Step 10
cmiS3
Step 11Load
cmiS5;cmiP1
Step 12M4
cmiP1
+Malonyl-CoA
Inactive: DH
Step 13M5
cmiP1
+Malonyl-CoA
Step 14M6
cmiP5
+Malonyl-CoA
Step 15M7
cmiP5
+Malonyl-CoA
Step 16M8
cmiP8
+Malonyl-CoA
Step 17M9
cmiP7
+Malonyl-CoA
Step 18M10
cmiP7
+Methylmalonyl-CoA
Step 19M11
cmiP7
+Malonyl-CoA
Step 20M12
cmiP6
+Malonyl-CoA
Step 21
cmiM6
Step 22TE
cmiP6
Step 23
cmiM3,cmiM4,cmiM1?,cmiM…
Step 31
cmiM5
Step 32
cmiC1
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions32 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
142-1cmiP4Loading
Methylmalonyl-CoA
O=C(O)CC
242-2cmiP4M1
42-1;Malonyl-CoA
from: 42-1
CCCCC(O)=O
342-3cmiP4M2
42-2;Malonyl-CoA
from: 42-2
CCCCCCC(O)=O
442-4cmiP3;cmiP2M3
42-3;Malonyl-CoA
from: 42-3
CCCCCC/C=C/C(O)=O
542-5Start
Glycine
NC([H])C(O)=O
642-6cmiS1
42-4;42-5
from: 42-4, 42-5
CCCCCCC(NCC(O)=O)CC(O)=O
742-7cmiS2
42-6
from: 42-6
CCCCCCC(N)CC(O)=O
842-8cmiS6;cmiS4
42-7
from: 42-7
CCCCCCC(N)CC(O)=O
942-9Start
L-amino acid
OC([C@@H](N)[R*])=O
1042-10cmiS3
42-8;42-9
from: 42-8, 42-9
CCCCCCC(NC([C@H]([R])N)=O)CC(O)=O
1142-11cmiS5;cmiP1Loading
42-10
from: 42-10
CCCCCCC([R])CC(O)=O
1242-12cmiP1M4
42-11;Malonyl-CoA
from: 42-11
CCCCCCC([R])CC(CC(O)=O)=O{'Inactive': ['DH']}
1342-13cmiP1M5
42-12;Malonyl-CoA
from: 42-12
CCCCCCC([R])CC(CCCC(O)=O)=O
1442-14cmiP5M6
42-13;Malonyl-CoA
from: 42-13
CCCCCCC([R])CC(CCC[C@H](O)CC(O)=O)=O
1542-15cmiP5M7
42-14;Malonyl-CoA
from: 42-14
CCCCCCC([R])CC(CCC[C@H](O)CC(CC(O)=O)=O)=O
1642-16cmiP8M8
42-15;Malonyl-CoA
from: 42-15
CCCCCCC([R])CC(CCC[C@H](O)CC(C[C@H](O)CC(O)=O)=O)=O
1742-17cmiP7M9
42-16;Malonyl-CoA
from: 42-16
CCCCCCC([R])CC(CCC[C@H](O)CC(C[C@H](O)C/C=C/C(O)=O)=O)=O
1842-18cmiP7M10
42-17;Methylmalonyl-CoA
from: 42-17
CCCCCCC([R])CC(CCC[C@H](O)CC(C[C@H](O)C/C=C/C=C(C(O)=O)\C)=O)=O
1942-19cmiP7M11
42-18;Malonyl-CoA
from: 42-18
CCCCCCC([R])CC(CCC[C@H](O)CC(C[C@H](O)C/C=C/C=C(/C=C/C(O)=O)C)=O)=O
2042-20cmiP6M12
42-19;Malonyl-CoA
from: 42-19
CCCCCCC([R])CC(CCC[C@H](O)CC(C[C@H](O)C/C=C/C=C(/C=C/C=C/C(O)=O)C)=O)=O
2142-21cmiM6
42-20
from: 42-20
CCCCCCC(N)CC(CCC[C@H](O)CC(C[C@H](O)C/C=C/C=C(/C=C/C=C/C(O)=O)C)=O)=O
2242-22cmiP6TE
42-21
from: 42-21
O=C(NC(CCCCCC)CC(CCC[C@H](O)C1)=O)/C=C/C=C/C(C)=C\C=C\C[C@@H](O)CC1=O
2342-23cmiM3,cmiM4,cmiM1?,cmiM2?,cmiM7?
42-22
from: 42-22
O=C(NC(CCCCCC)CC(CCC[C@H](O)C1)=O)/C=C/C=C/C(C)=C\C2CC(O)C(O)=C2C1=O
2442-24Start
D-glucose-1-phosphate
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO
2542-25cmiC7
42-24
from: 42-24
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO
2642-26cmiC6
42-25
from: 42-25
C[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)C1=O
2742-27cmiC5
42-26
from: 42-26
C[C@H]1O[C@H]([R])CC(C1=O)=O
2842-28cmiC4
42-27
from: 42-27
C[C@H]1O[C@H]([R])C[C@H](O)C1=O
2942-29cmiC3
42-28
from: 42-28
C[C@H]1C([C@H](O)C[C@@H]([R])O1)=O
3042-30cmiC2
42-29
from: 42-29
C[C@H]1[C@H](O)[C@H](O)C[C@@H]([R])O1
3142-31cmiM5
42-23;42-30
from: 42-23, 42-30
O=C(NC(CCCCCC)CC(CCC[C@H](O)C1)=O)/C=C/C=C/C(C)=C\C2CC(OC3OC(C)C(O)C(O)C3)C(O)=C2C1=O
3242cmiC1
42-31
from: 42-31
O=C(NC(CCCCCC)CC(CCC[C@H](O)C1)=O)/C=C/C=C/C(C)=C\C2CC(OC3OC(C)C(O)C(OC)C3)C(O)=C2C1=O
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