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BGC0000040PKS

Concanamycin A

Producing organism
Streptomyces neyagawaensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
26
DOI
MIBiG entry
View on MIBiG ↗
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concanamycin A
C46H75NO14865.52 Da

Gene Cluster Map28 genes · 99,892 bp

20 kb99.9 kb visible · 99,892 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
ACPSACP synthase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

26 steps · 25 edges
Step 1Load
AAZ94386.1
+Malonyl-CoA
Step 16
?
+β-D-glucose-1-pho…
Step 2M1
AAZ94386.1
+Malonyl-CoA
Step 17
AAZ94397.1
Step 3M2
AAZ94387.1
+Methylmalonyl-CoA
Step 18
AAZ94396.1
Step 4M3
AAZ94387.1
+Malonyl-CoA
Step 19
AAZ94401.1
Step 5M4
AAZ94387.1
+Methylmalonyl-CoA
Inactive: KR
Step 20
Step 6M5
AAZ94388.1
+Methylmalonyl-CoA
Step 21(1)
AAZ94400.1
Step 21(2)
AAZ94399.1
Step 7M6
AAZ94388.1
+Methoxymalonyl-ACP
Step 22(1)
AAZ94399.1
Step 22(2)
AAZ94400.1
Step 8M7
AAZ94388.1
+Malonyl-CoA
Step 23
AAZ94398.1
Step 9M8
AAZ94389.1
+Methylmalonyl-CoA
Step 10M9
AAZ94389.1
+Methylmalonyl-CoA
Step 11M10
AAZ94390.1
+Ethylmalonyl-CoA
Step 12M11
AAZ94390.1
+Methylmalonyl-CoA
Step 13M12
AAZ94390.1
+Methylmalonyl-CoA
Step 14M13
AAZ94391.1
+Methoxymalonyl-ACP
Step 15TE
AAZ94391.1
Step 24
AAZ94402.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions26 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
140-1AAZ94386.1Loading
Malonyl-CoA
O=C(O)C—
240-2AAZ94386.1M1
40-1;Malonyl-CoA
from: 40-1
C/C=C/C(O)=O—
340-3AAZ94387.1M2
40-2;Methylmalonyl-CoA
from: 40-2
C/C=C/[C@@H](O)[C@@H](C)C(O)=O—
440-4AAZ94387.1M3
40-3;Malonyl-CoA
from: 40-3
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC(O)=O—
540-5AAZ94387.1M4
40-4;Methylmalonyl-CoA
from: 40-4
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC([C@@H](C)C(O)=O)=O{'Inactive': ['KR']}
640-6AAZ94388.1M5
40-5;Methylmalonyl-CoA
from: 40-5
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC([C@@H](C)[C@H](O)[C@H](C)C(O)=O)=O—
740-7AAZ94388.1M6
40-6;Methoxymalonyl-ACP
from: 40-6
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](OC)C(O)=O)=O—
840-8AAZ94388.1M7
40-7;Malonyl-CoA
from: 40-7
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](OC)/C=C/C(O)=O)=O—
940-9AAZ94389.1M8
40-8;Methylmalonyl-CoA
from: 40-8
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](OC)/C=C/C=C(C)/C(O)=O)=O—
1040-10AAZ94389.1M9
40-9;Methylmalonyl-CoA
from: 40-9
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)C(O)=O)=O—
1140-11AAZ94390.1M10
40-10;Ethylmalonyl-CoA
from: 40-10
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)C(O)=O)=O—
1240-12AAZ94390.1M11
40-11;Methylmalonyl-CoA
from: 40-11
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)C(O)=O)=O—
1340-13AAZ94390.1M12
40-12;Methylmalonyl-CoA
from: 40-12
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C(O)=O)=O—
1440-14AAZ94391.1M13
40-13;Methoxymalonyl-ACP
from: 40-13
C/C=C/[C@@H](O)[C@@H](C)[C@H](O)CC([C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C=C(OC)/C(O)=O)=O—
1540-15AAZ94391.1TE
40-14
from: 40-14
OC([C@H](C)[C@]1(O)O[C@H](/C=C/C)[C@@H](C)[C@H](O)C1)[C@H](C)[C@@H]2[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C=C(OC)/C(O2)=O—
1640-16?—
β-D-glucose-1-phosphate
[R]O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
1740-17AAZ94397.1—
40-16
from: 40-16
[R][C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
1840-18AAZ94396.1—
40-17
from: 40-17
[R][C@H](O[C@@H]1C)[C@H](O)[C@@H](O)C1=O—
1940-19AAZ94401.1—
40-18
from: 40-18
[R][C@H](O[C@@H]1C)C=C(O)C1=O—
2040-20—
40-19
from: 40-19
[R][C@H](O[C@H](C)C1=O)CC1=O—
21(1)40-21AAZ94400.1—
40-20
from: 40-20
[R][C@H](O[C@@H]1C)C[C@@H](O)C1=O—
21(2)40-22AAZ94399.1—
40-20
from: 40-20
[R][C@H](O[C@H](C)[C@H]1O)CC1=O—
22(1)40-23AAZ94399.1—
40-21
from: 40-21
[R][C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1—
22(2)40-23AAZ94400.1—
40-22
from: 40-22
[R][C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1—
2340-24AAZ94398.1—
40-23
from: 40-23
[R][C@H]1C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O1—
2440AAZ94402.1—
40-15;40-24
from: 40-15, 40-24
C[C@@H]([C@@H](O)[C@@H]([C@@]1(C[C@@H]([C@H]([C@H](O1)O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)C)/C=C/C)O)C)[C@H]([C@H](/C=C/C=C(C[C@H]([C@H](O)[C@@H]([C@@H]3O)CC)C)\C)OC)OC(/C(OC)=C/C(C)=C/[C@H]3C)=O—
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