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BGC0000038PKS

Coelimycin P1

Producing organism
Streptomyces coelicolor A3(2)
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces albidoflavus group
Biosynthetic class
PKS (Type I)
Total steps
19
DOI
MIBiG entry
View on MIBiG ↗
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coelimycin P1
C17H20N2O4S348.11 Da

Gene Cluster Map24 genes · 57,887 bp

KSATKSATKSATKSATKSATKSATAmT10 kb57.9 kb visible · 57,887 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
TDTerminal reductase
AmTAminotransferase III

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1Load
SCO6275
+Malonyl-CoA
Step 9
Start
+PMP
Step 15
Start
Step 2M1
SCO6275
+Malonyl-CoA
Step 3M2
SCO6275
+Malonyl-CoA
Step 4M3
SCO6274
+Malonyl-CoA
Step 5M4
SCO6274
+Malonyl-CoA
Inactive: DH
Step 6M5
SCO6273
+Malonyl-CoA
Step 7
?
Step 8
SCO6277?
Step 10
SCO6279
Step 11(1)
SCO6276/SCO6278/SCO6281
Step 11(2)
SCO6276/SCO6278/SCO6281
Step 12
SCO6276/SCO6278/SCO6281
Step 13
SCO6276/SCO6278/SCO6281
Step 14
?
Step 16
?
Step 17
?
Step 18
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
138-1SCO6275Loading
Malonyl-CoA
O=C(C)O—
238-2SCO6275M1
38-1;Malonyl-CoA
from: 38-1
C/C=C/C(O)=O—
338-3SCO6275M2
38-2;Malonyl-CoA
from: 38-2
C/C=C/C=C/C(O)=O—
438-4SCO6274M3
38-3;Malonyl-CoA
from: 38-3
C/C=C/C=C/C=C/C(O)=O—
538-5SCO6274M4
38-4;Malonyl-CoA
from: 38-4
C/C=C/C=C/C=C/[C@@H](O)CC(O)=O{'Inactive': ['DH']}
638-6SCO6273M5
38-5;Malonyl-CoA
from: 38-5
C/C=C/C=C/C=C/[C@@H](O)C/C=C/C(O)=O—
738-7?—
38-6
from: 38-6
C/C=C/C=C/C=C/[C@@H](O)C/C=C/C=O—
838-8SCO6277?—
38-7
from: 38-7
C/C=C/C=C/C=C/[C@@H](O)/C=C\CC=O—
938-9Start—
PMP
NCC1=C(O)C(C)=NC=C1COP(O)(O)=O—
1038-10SCO6279—
38-8;38-9
from: 38-8, 38-9
C/C=C/C=C/C=C/[C@@H](O)/C=C\CCN—
11(1)38-11SCO6276/SCO6278/SCO6281—
38-10
from: 38-10
C/C=C/C=C/C(O1)C1[C@@H](O)/C=C\CCN—
11(2)38-12SCO6276/SCO6278/SCO6281—
38-10
from: 38-10
C/C=C/C(O1)C1/C=C/[C@@H](O)/C=C\CCN—
1238-13SCO6276/SCO6278/SCO6281—
38-11/38-12
from: 38-11/38-12
C/C=C/C(O1)C1C(O2)C2[C@@H](O)/C=C\CCN—
1338-14SCO6276/SCO6278/SCO6281—
38-13
from: 38-13
C/C=C/C(O1)C1C(O2)C2C3(O)C=CCCN3—
1438-15?—
38-14
from: 38-14
C/C=C/C(O1)C1C(O2)C2C3=NCCC=C3—
1538-16Start—
[R][C@H](C(O)=O)CS—
1638-17?—
38-15;38-16
from: 38-15, 38-16
C/C=C/C(O1)C1C(O)C(SCC([R])C(O)=O)C2C=CCCN2—
1738-18?—
38-17
from: 38-17
C/C=C/C(O)C(O1)C(O)C(SC[C@H](C)C1=O)C2C=CCCN2—
1838?—
38-18
from: 38-18
O=C(C)NC1C(O/C(C(/C=C/C)=O)=C\C(SC1)=C2NCCC=C/2)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture