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BGC0000036PKS

Chlorothricin;Deschlorothricin

Producing organism
Streptomyces antibioticus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I);Saccharide
Total steps
32
DOI
MIBiG entry
View on MIBiG ↗
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C49H61ClO16940.36 Da

Gene Cluster Map43 genes · 111,968 bp

20 kb112.0 kb visible · 111,968 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

32 steps · 33 edges
Step 1Load
AAZ77693.1
+Malonyl-CoA
Step 14
AAZ77703.1;AAZ77704.1
Step 20
Start
+Glucose-1-phospha…
Step 26
AAZ77673.1
Step 2M1
AAZ77693.1
+Methylmalonyl-CoA
Step 15
AAZ77705.1
Step 21
AAZ77690.1
Step 27
?
Step 3M2
AAZ77693.1
+Malonyl-CoA
Step 16
AAZ77706.1
Step 22
AAZ77689.1
Step 28
AAZ77675.1;AAZ77676.1
Step 4M3
AAZ77694.1
+Malonyl-CoA
Step 17
?
Step 23
AAZ77682.1
Step 29
AAZ77678.1
Step 5M4
AAZ77694.1
+Malonyl-CoA
Step 18
?
Step 24
AAZ77681.1
Step 30
AAZ77674.1
Step 6M5
AAZ77696.1
+Malonyl-CoA
Step 19
AAZ77692.1;AAZ77695.1;A…
Step 25
AAZ77680.1
Step 7M6
AAZ77696.1
+Malonyl-CoA
Step 31(1)
AAZ77672.1;AAZ77679.1;A…
Step 31(2)
AAZ77672.1;AAZ77679.1;A…
Step 8M7
AAZ77696.1
+Malonyl-CoA
Step 9M8
AAZ77697.1
+Malonyl-CoA
Inactive: DH
Step 10M9
AAZ77698.1
+Malonyl-CoA
Step 11M10
AAZ77698.1
+Methylmalonyl-CoA
Step 12M11
AAZ77699.1
+Malonyl-CoA
Step 13
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions32 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
136-1AAZ77693.1Loading
Malonyl-CoA
O=C(C)O—
236-2AAZ77693.1M1
36-1;Methylmalonyl-CoA
from: 36-1
C/C=C(C(O)=O)\C—
336-3AAZ77693.1M2
36-2;Malonyl-CoA
from: 36-2
C/C=C(/C=C/C(O)=O)C—
436-4AAZ77694.1M3
36-3;Malonyl-CoA
from: 36-3
C/C=C(/C=C/C=C/C(O)=O)C—
536-5AAZ77694.1M4
36-4;Malonyl-CoA
from: 36-4
C/C=C(/C=C/C=C/CCC(O)=O)C—
636-6AAZ77696.1M5
36-5;Malonyl-CoA
from: 36-5
C/C=C(/C=C/C=C/CCCCC(O)=O)C—
736-7AAZ77696.1M6
36-6;Malonyl-CoA
from: 36-6
C/C=C(/C=C/C=C/CCCC/C=C/C(O)=O)C—
836-8AAZ77696.1M7
36-7;Malonyl-CoA
from: 36-7
C/C=C(/C=C/C=C/CCCC/C=C/C=C/C(O)=O)C—
936-9AAZ77697.1M8
36-8;Malonyl-CoA
from: 36-8
C/C=C(/C=C/C=C/CCCC/C=C/C=C/[C@@H](O)CC(O)=O)C{'Inactive': ['DH']}
1036-10AAZ77698.1M9
36-9;Malonyl-CoA
from: 36-9
C/C=C(/C=C/C=C/CCCC/C=C/C=C/[C@@H](O)CCCC(O)=O)C—
1136-11AAZ77698.1M10
36-10;Methylmalonyl-CoA
from: 36-10
C/C=C(/C=C/C=C/CCCC/C=C/C=C/[C@@H](O)CCC/C=C(C)/C(O)=O)C—
1236-12AAZ77699.1M11
36-11;Malonyl-CoA
from: 36-11
C/C=C(/C=C/C=C/CCCC/C=C/C=C/[C@@H](O)CCC/C=C(C)/C(CC(O)=O)=O)C—
1336-13?—
36-12
from: 36-12
O[C@@H](CCC/C=C(C)\C(CC(O)=O)=O)/C=C/C=C/CCCC/C=C/C=C/C(C)=C/C—
1436-14AAZ77703.1;AAZ77704.1—
OC(C(O)=O)CO—
1536-15AAZ77705.1—
36-14
from: 36-14
OC(C(O)=O)=C—
1636-16AAZ77706.1—
36-14;36-15
from: 36-14, 36-15
O[C@@H]1[C@]2([H])[C@H]([C@@](C([CH-]C(OC(C(O)=O)=C)=O)=O)(C)C(C=C2)CCCC/C=C/C=C/C(C)=C/C)CCC1—
1736-17?—
36-16
from: 36-16
O[C@@H]1[C@]2([H])[C@H]([C@@](/C(O)=C3C(C(OC\3=O)=C)=O)(C)C(C=C2)CCCC/C=C/C=C/C(C)=C/C)CCC1—
1836-18?—
36-17
from: 36-17
O[C@@H]1[C@]2([H])[C@H]([C@@]3(C)[C@@H](C=C2)CCCC/C=C/[C@@H]4C=C(C)[C@H](C)C[C@]54C(O)=C(C(O5)=O)C3=C)CCC1—
1936-19AAZ77692.1;AAZ77695.1;AAZ77700.1—
36-18
from: 36-18
O[C@@H]1[C@]2([H])[C@H]([C@@]3(C)[C@@H](C=C2)CCCC/C=C/[C@@H]4C=C(C(O)=O)[C@H](C)C[C@]54C(O)=C(C(O5)=O)C3=C)CCC1—
2036-20Start—
Glucose-1-phosphate
[R][C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
2136-21AAZ77690.1—
36-20
from: 36-20
[R][C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
2236-22AAZ77689.1—
36-21
from: 36-21
[R][C@@H](O[C@@H]1C)[C@H](O)[C@@H](O)C1=O—
2336-23AAZ77682.1—
36-22
from: 36-22
[R][C@@H](O[C@@H]1C)CC(C1=O)=O—
2436-24AAZ77681.1—
36-23
from: 36-23
[R][C@@H](O[C@@H]1C)C[C@@H](O)C1=O—
2536-25AAZ77680.1—
36-24
from: 36-24
[R][C@@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1—
2636-26AAZ77673.1—
O=C(CC([R])=O)C[C@@H](O)CC(C)=O—
2736-27?—
36-26
from: 36-26
OC1=CC=CC(C)=C1C(O)=O—
2836-28AAZ77675.1;AAZ77676.1—
36-27
from: 36-27
OC1=CC=CC(C)=C1C(O)=O—
2936-29AAZ77678.1—
36-28
from: 36-28
CC1=C(C(O)=O)C(OC)=CC=C1—
3036-30AAZ77674.1—
36-29
from: 36-29
CC1=C(C(O)=O)C(OC)=CC=C1Cl—
31(1)36(1)AAZ77672.1;AAZ77679.1;AAZ77691.1—
36-19;36-25;36-30
from: 36-19, 36-25, 36-30
C[C@]1([C@H]2[C@@]3([H])[C@@H](O[C@H]4C[C@@H](O)[C@H](O[C@@H]5O[C@H](C)[C@@H](O)[C@H](OC(C6=C(C)C(Cl)=CC=C6OC)=O)C5)[C@H](C)O4)CCC2)[C@@H](C=C3)CCCC/C=C/[C@@H]7C=C(C(O)=O)[C@H](C)C[C@]87C(O)=C(C(O8)=O)C1=C—
31(2)36(2)AAZ77672.1;AAZ77679.1;AAZ77691.1—
36-19;36-25;36-30
from: 36-19, 36-25, 36-30
C[C@]1([C@H]2[C@@]3([H])[C@@H](O[C@H]4C[C@@H](O)[C@H](O[C@@H]5O[C@H](C)[C@@H](O)[C@H](OC(C6=C(C)C=CC=C6OC)=O)C5)[C@H](C)O4)CCC2)[C@@H](C=C3)CCCC/C=C/[C@@H]7C=C(C(O)=O)[C@H](C)C[C@]87C(O)=C(C(O8)=O)C1=C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture