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BGC0000035PKS

Chalcomycin

Producing organism
Streptomyces bikiniensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
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chalcomycin A
C35H56O14700.37 Da

Gene Cluster Map41 genes · 85,915 bp

KSKSKSKSKSKSKSKS20 kb85.9 kb visible · 85,915 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

17 steps · 17 edges
Step 1Load
chmGI
+Malonyl-CoA
Step 9
Start
+Glucose-1-Phospha…
Step 2M1
chmGI
+Methylmalonyl-CoA
Step 10
chmAI
Step 3M2
chmGI
+Malonyl-CoA
Step 11
chmAII
Step 4M3
chmGII
+Malonyl-CoA
Step 12
chmCIV, chmCV, chmCII?
Step 15
chmJ
Step 5M4
chmGIII
+Methylmalonyl-CoA
Step 13
?
Step 16
chmD
Step 6M5
chmGIII
+Methylmalonyl-CoA
Step 14
chmCI
Step 7M6
chmGIV
+Methylmalonyl-CoA
Step 8M7
chmGV
+Malonyl-CoA
Step 17
chmGV,chmCIII,(chmHI;ch…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
135-1chmGILoading
Malonyl-CoA
O=C(O)C—
235-2chmGIM1
35-1;Methylmalonyl-CoA
from: 35-1
C[C@@H](O)[C@@H](C)C(O)=O—
335-3chmGIM2
35-2;Malonyl-CoA
from: 35-2
C[C@@H](O)[C@@H](C)/C=C/C(O)=O—
435-4chmGIIM3
35-3;Malonyl-CoA
from: 35-3
C[C@@H](O)[C@@H](C)/C=C/C=C/C(O)=O—
535-5chmGIIIM4
35-4;Methylmalonyl-CoA
from: 35-4
C[C@@H](O)[C@@H](C)/C=C/C=C/C([C@H](C)C(O)=O)=O—
635-6chmGIIIM5
35-5;Methylmalonyl-CoA
from: 35-5
C[C@@H](O)[C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)C(O)=O)=O—
735-7chmGIVM6
35-6;Methylmalonyl-CoA
from: 35-6
C[C@@H](O)[C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)[C@H](O)[C@@H](C)C(O)=O)=O—
835-8chmGVM7
35-7;Malonyl-CoA
from: 35-7
C[C@@H](O)[C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)[C@H](O)[C@@H](C)C(CC(O)=O)=O)=O—
935-9Start—
Glucose-1-Phosphate
O[C@H]1[C@H](O)[C@@H](O)[C@H]([R])O[C@@H]1CO—
1035-10chmAI—
35-9
from: 35-9
O[C@H]1[C@H](O)[C@@H](O)[C@H]([R])O[C@@H]1CO—
1135-11chmAII—
35-10
from: 35-10
O[C@H]([C@@H](O)[C@H]([R])O[C@@H]1C)C1=O—
1235-12chmCIV, chmCV, chmCII?—
35-11
from: 35-11
C[C@H]1O[C@@H]([R])[C@H](O)C(C1)=O—
1335-13?—
35-12
from: 35-12
C[C@H]1O[C@@H]([R])[C@H](O)[C@@H](O)C1—
1435-14chmCI—
35-13
from: 35-13
C[C@H]1O[C@@H]([R])[C@H](O)[C@@H](OC)C1—
1535-15chmJ—
35-11
from: 35-11
C[C@H]1O[C@@H]([R])[C@H](O)[C@H](O)C1=O—
1635-16chmD—
35-15
from: 35-15
C[C@H]1O[C@@H]([R])[C@H](O)[C@H](O)[C@@H]1O—
1735chmGV,chmCIII,(chmHI;chmHII),chmN,chmMI,chmMII,chmPI,chmPII,?,?—
35-8;35-14;35-16
from: 35-8, 35-14, 35-16
O=C1CC(O[C@H](C)[C@@H](CO[C@H]2[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O2)[C@@H](O3)[C@H]3/C=C/C([C@@](C)(O)C[C@H](C)[C@H](O[C@@H]4[C@H](O)[C@@H](OC)C[C@@H](C)O4)[C@H]1C)=O)=O—
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