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BGC0000034Hybrid

Candicidin

Producing organism
Streptomyces sp. FR-008
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
30
DOI
MIBiG entry
View on MIBiG ↗
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candicidin
C59H84N2O181108.57 Da

Gene Cluster Map21 genes · 138,203 bp

20 kb138.2 kb visible · 138,203 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
AmTAminotransferase IV
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

30 steps · 29 edges
Step 1
Start
+Chorismate
Step 27
Start
+Mycosamine
Step 2
pabAB
Step 3
pabC
Step 4Load
fscA
Step 5M1
fscA
+Malonyl-CoA
Step 6M2
fscB
+Methylmalonyl-CoA
Step 7M3
fscB
+Methylmalonyl-CoA
Step 8M4
fscB
+Methylmalonyl-CoA
Inactive: DH
Step 9M5
fscC
+Malonyl-CoA
Step 10M6
fscC
+Malonyl-CoA
Step 11M7
fscC
+Malonyl-CoA
Step 12M8
fscC
+Malonyl-CoA
Step 13M9
fscC
+Malonyl-CoA
Step 14M10
fscC
+Malonyl-CoA
Step 15M11
fscD
+Malonyl-CoA
Step 16M12
fscD
+Malonyl-CoA
Step 17M13
fscD
+Methylmalonyl-CoA
Step 18M14
fscD
+Malonyl-CoA
Step 19M15
fscD
+Malonyl-CoA
Inactive: KR
Step 20M16
fscD
+Malonyl-CoA
Step 21M17
fscE
+Malonyl-CoA
Inactive: DH, ER
Step 22M18
fscE
+Malonyl-CoA
Step 23M19
fscE
+Malonyl-CoA
Inactive: KR
Step 24M20
fscE
+Malonyl-CoA
Step 25M21
fscF
+Malonyl-CoA
Inactive: DH, KR
Step 26TE
fscF
Step 28
fscP, fscFE, fscMI
Step 29
fscO
Step 30
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions30 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
134-1Start—
Chorismate
OC(C1=C[C@@H](OC(C(O)=O)=C)[C@H](O)C=C1)=O—
234-2pabAB—
34-1
from: 34-1
OC(C1=C[C@@H](OC(C(O)=O)=C)[C@H](N)C=C1)=O—
334-3pabC—
34-2
from: 34-2
OC(C1=CC(O)=C(N)C=C1)=O—
434-4fscALoading
34-3
from: 34-3
OC(C1=CC=C(N)C=C1)=O—
534-5fscAM1
34-4;Malonyl-CoA
from: 34-4
O=C(CC(O)=O)C1=CC=C(N)C=C1—
634-6fscBM2
34-5;Methylmalonyl-CoA
from: 34-5
O=C(CC(O)C(C(O)=O)C)C1=CC=C(N)C=C1—
734-7fscBM3
34-6;Methylmalonyl-CoA
from: 34-6
O=C(CC(O)C(CC(C(O)=O)C)C)C1=CC=C(N)C=C1—
834-8fscBM4
34-7;Methylmalonyl-CoA
from: 34-7
O=C(CC(O)C(CC(C(O)C(C(O)=O)C)C)C)C1=CC=C(N)C=C1{'Inactive': ['DH']}
934-9fscCM5
34-8;Malonyl-CoA
from: 34-8
O=C(O)/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
1034-10fscCM6
34-9;Malonyl-CoA
from: 34-9
O=C(O)/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
1134-11fscCM7
34-10;Malonyl-CoA
from: 34-10
O=C(O)/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
1234-12fscCM8
34-11;Malonyl-CoA
from: 34-11
O=C(O)/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
1334-13fscCM9
34-12;Malonyl-CoA
from: 34-12
O=C(O)/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
1434-14fscCM10
34-13;Malonyl-CoA
from: 34-13
O=C(O)/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
1534-15fscDM11
34-14;Malonyl-CoA
from: 34-14
O=C(O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
1634-16fscDM12
34-15;Malonyl-CoA
from: 34-15
O=C(O)CC(O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
1734-17fscDM13
34-16;Methylmalonyl-CoA
from: 34-16
OC(CC(O)C(C)C(O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
1834-18fscDM14
34-17;Malonyl-CoA
from: 34-17
OC(CC(O)C(C)C(O)CC(O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
1934-19fscDM15
34-18;Malonyl-CoA
from: 34-18
OC(CC(O)C(C)C(O)CC(CC(O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O{'Inactive': ['KR']}
2034-20fscDM16
34-19;Malonyl-CoA
from: 34-19
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
2134-21fscEM17
34-20;Malonyl-CoA
from: 34-20
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)CC(O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O{'Inactive': ['DH', 'ER']}
2234-22fscEM18
34-21;Malonyl-CoA
from: 34-21
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)CCCC(O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
2334-23fscEM19
34-22;Malonyl-CoA
from: 34-22
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)CCCC(CC(O)=O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O{'Inactive': ['KR']}
2434-24fscEM20
34-23;Malonyl-CoA
from: 34-23
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)CCCC(CCCC(O)=O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CC(C)C(O)CC(C1=CC=C(N)C=C1)=O—
2534-25fscFM21
34-24;Malonyl-CoA
from: 34-24
CC(C(OC(CC(CCCC(CCCC(O)CC(O)C1)=O)=O)=O)C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC1=O)CC(C(CC(C2=CC=C(C=C2)N)=O)O)C{'Inactive': ['DH', 'KR']}
2634-26fscFTE
34-25
from: 34-25
CC(C(CC(CC(CCCC(CCCC(O)CC(O)C1)=O)=O)=O)C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC1=O)CC(C(CC(C2=CC=C(C=C2)N)=O)O)C—
2734-27Start—
Mycosamine
O[C@H]1[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O1—
2834-28fscP, fscFE, fscMI—
34-26;34-27
from: 34-26, 34-27
CC(C(OC(CC(CCCC(CCCC(O)CC(O)C1)=O)=O)=O)C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)CC(O)C(C(O)=O)C(O)CC1=O)CC(C(CC(C3=CC=C(C=C3)N)=O)O)C—
2934-29fscO—
34-28
from: 34-28
CC(C(OC(CC(CCCC(CC(O)CC(O)CC(O)C1)=O)=O)=O)C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)CC(O)C(C(O)=O)C(O)CC1=O)CC(C(CC(C3=CC=C(C=C3)N)=O)O)C—
3034?—
34-29
from: 34-29
CC(C(OC(CC(CCC1)=O)=O)C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)CC(O3)C(C(O)=O)C(O)CC3(O)CC(O)CC(O)CC(O)CC1=O)CC(C(CC(C4=CC=C(C=C4)N)=O)O)C—
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