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BGC0000032PKS

A23187

Producing organism
Streptomyces chartreusis NRRL 3882
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
21
DOI
MIBiG entry
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A23187
C29H37N3O6523.27 Da

Gene Cluster Map29 genes · 68,313 bp

AKSKSKSAKSKSKSKS10 kb68.3 kb visible · 68,313 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
CycPolyketide cyclase

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1
Start
+L-Proline
Step 11
Start
+Chorismate
Step 2
SchN2;SchN3
Step 12
SchB1
Step 3
SchN1
Step 13
SchB2
Step 4
SchN1/Spontaneous
Step 14
SchB3
Step 5M1
SchA1
+Methylmalonyl-CoA
Step 6M2
SchA1
+Methylmalonyl-CoA
Step 7M3
SchA2
+Methylmalonyl-CoA
Step 8M4
SchA5
+Malonyl-CoA
Inactive: DH, KR
Step 9M5
SchA5
+Methylmalonyl-CoA
Step 10M6
SchA4
+Malonyl-CoA
Step 15
?
Step 16
?
Step 17
?
Step 18
Step 19
?
Step 20
?
Step 21
SchM
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
132-1Start—
L-Proline
OC([C@H]1NCCC1)=O—
232-2SchN2;SchN3—
32-1
from: 32-1
OC([C@H]1NCCC1)=O—
332-3SchN1—
32-2
from: 32-2
OC(C1=CCCN1)=O—
432-4SchN1/Spontaneous—
32-3
from: 32-3
OC(C1=CC=CN1)=O—
532-5SchA1M1
32-4;Methylmalonyl-CoA
from: 32-4
O=C(C(C)C(O)=O)C1=CC=CN1—
632-6SchA1M2
32-5;Methylmalonyl-CoA
from: 32-5
O=C(C(C)C(O)C(C)C(O)=O)C1=CC=CN1—
732-7SchA2M3
32-6;Methylmalonyl-CoA
from: 32-6
O=C(C(C)C(O)C(C)CC(C)C(O)=O)C1=CC=CN1—
832-8SchA5M4
32-7;Malonyl-CoA
from: 32-7
O=C(C(C)C(O)C(C)CC(C)C(CC(O)=O)=O)C1=CC=CN1{'Inactive': ['DH', 'KR']}
932-9SchA5M5
32-8;Methylmalonyl-CoA
from: 32-8
O=C(C(C)C(O)C(C)CC(C)C(CCC(C)C(O)=O)=O)C1=CC=CN1—
1032-10SchA4M6
32-9;Malonyl-CoA
from: 32-9
O=C(C(C)C(O)C(C)CC(C)C(CCC(C)C(O)CC(O)=O)=O)C1=CC=CN1—
1132-11Start—
Chorismate
OC1C=CC(C(O)=O)=C[C@H]1OC(C([O-])=O)=C—
1232-12SchB1—
32-11
from: 32-11
OC1C=CC(C(O)=O)=C(N)[C@H]1OC(C([O-])=O)=C—
1332-13SchB2—
32-12
from: 32-12
O[C@@H](C=CC=C1C(O)=O)[C@H]1N—
1432-14SchB3—
32-13
from: 32-13
OC(C=CC=C1C(O)=O)=C1N—
1532-15?—
32-10;32-14
from: 32-10, 32-14
O=C([C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)C(CC[C@@H](C)[C@H](O)CC(NC1=C(O)C=CC=C1C(O)=O)=O)=O)C2=CC=CN2—
1632-16?—
32-15
from: 32-15
O=C([C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)C(CC[C@@H](C)[C@H](O)CC1(O)OC2=C(N1)C(C(O)=O)=CC=C2)=O)C3=CC=CN3—
1732-17?—
32-16
from: 32-16
O=C([C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)C(CC[C@@H](C)[C@H](O)CC1=NC2=C(O1)C=CC=C2C(O)=O)=O)C3=CC=CN3—
1832-18—
32-17
from: 32-17
O=C([C@@H](C)[C@]1([H])[C@H](C)C[C@@H](C)[C@@]2(O[C@@](CC3=NC4=C(O3)C=CC=C4C(O)=O)([H])[C@H](C)CC2)O1)C5=CC=CN5—
1932-19?—
32-18
from: 32-18
O=C([C@@H](C)[C@]1([H])[C@H](C)C[C@@H](C)[C@@]2(O[C@@](CC3=NC4=C(O3)C=CC(O)=C4C(O)=O)([H])[C@H](C)CC2)O1)C5=CC=CN5—
2032-20?—
32-19
from: 32-19
O=C([C@@H](C)[C@]1([H])[C@H](C)C[C@@H](C)[C@@]2(O[C@@](CC3=NC4=C(O3)C=CC(N)=C4C(O)=O)([H])[C@H](C)CC2)O1)C5=CC=CN5—
2132SchM—
32-20
from: 32-20
O=C([C@@H](C)[C@]1([H])[C@H](C)C[C@@H](C)[C@@]2(O[C@@](CC3=NC4=C(O3)C=CC(NC)=C4C(O)=O)([H])[C@H](C)CC2)O1)C5=CC=CN5—
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