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BGC0000031PKS

Borrelidin

Producing organism
Streptomyces parvulus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
21
DOI
MIBiG entry
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borrelidin
C28H43NO6489.31 Da

Gene Cluster Map43 genes · 74,787 bp

KSKSKSKSKSKS10 kb74.8 kb visible · 74,787 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
CycPolyketide cyclase
AmTAminotransferase III

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1
Start
+5-oxo-pent-3-ene-…
Step 2
borN
Step 3
borN
Step 4
borM;borC;borD
Step 5
borM;borC;borD
Step 6
borF
Step 7
borE
Step 8Load
borA1
Step 9M1
borA2
+Malonyl-CoA
Step 10M2
borA3
+Malonyl-CoA
Step 11M3
borA3
+Methylmalonyl-CoA
Step 12M4
borA4
+Methylmalonyl-CoA
Step 13M5
borA5
Iterative
Step 14M6
borA6
+Malonyl-CoA
Step 15TE
borA6
Step 16
borI
Step 17
borI;borK
Step 18
borJ
Step 19
borI
Step 20
borI
Step 21
borI
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
131-1Start—
5-oxo-pent-3-ene-1,2,5-tricarboxylic acid
OC(CC(C(O)=O)/C=C\C(C(O)=O)=O)=O—
231-2borN—
31-1
from: 31-1
OC(C/C=C/C=C(O)\C(O)=O)=O—
331-3borN—
31-2
from: 31-2
OC(CC/C=C\C(C(O)=O)=O)=O—
431-4borM;borC;borD—
31-3
from: 31-3
OC(CCCCC(C(O)=O)=O)=O—
531-5borM;borC;borD—
31-4
from: 31-4
OC(CCCCC(O)C(O)=O)=O—
631-6borF—
31-5
from: 31-5
OC(CCCCC(O[R])C(O)=O)=O—
731-7borE—
31-6
from: 31-6
O=C(O)[C@H]1[C@H](C(O)=O)CCC1—
831-8borA1Loading
31-7
from: 31-7
O=C(O)[C@@]1([H])[C@H](C(O)=O)CCC1—
931-9borA2M1
31-8;Malonyl-CoA
from: 31-8
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)CC(O)=O—
1031-10borA3M2
31-9;Malonyl-CoA
from: 31-9
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)C/C=C/C(O)=O—
1131-11borA3M3
31-10;Methylmalonyl-CoA
from: 31-10
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)C/C=C/C=C(C(O)=O)\C—
1231-12borA4M4
31-11;Methylmalonyl-CoA
from: 31-11
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)C/C=C/C=C([C@H](O)[C@H](C(O)=O)C)\C—
1331-13borA5M5
31-12
from: 31-12
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)C/C=C/C=C([C@H](O)[C@H](C[C@H](C[C@H](C[C@H](C(O)=O)C)C)C)C)\C{'Iteration': [(['DH', 'KR']…
1431-14borA6M6
31-13;Malonyl-CoA
from: 31-13
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)C/C=C/C=C([C@H](O)[C@H](C[C@H](C[C@H](C[C@H]([C@@H](O)CC(O)=O)C)C)C)C)\C—
1531-15borA6TE
31-14
from: 31-14
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(C)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
1631-16borI—
31-15
from: 31-15
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(CO)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
1731-17borI;borK—
31-16
from: 31-16
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(C([H])=O)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
1831-18borJ—
31-17
from: 31-17
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(CN)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
1931-19borI—
31-18
from: 31-18
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(CN(O)O)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
2031-20borI—
31-19
from: 31-19
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(/C=N/O)[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
2131borI—
31-20
from: 31-20
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(C#N)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture