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BGC0000029PKS

BE-14106

Producing organism
Streptomyces sp. DSM 21069
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
18
DOI
MIBiG entry
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BE-14106
C27H37NO3423.28 Da

Gene Cluster Map28 genes · 85,059 bp

KSKSKSKSKSKSAKSKSKSKSKSKS20 kb85.1 kb visible · 85,059 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1Load
becA
+Methylmalonyl-CoA
Step 4
Start
+Glycine
Step 2M1
becA
+Malonyl-CoA
Step 3M2
becA
+Malonyl-CoA
Step 5M3
becC;becI;becL;becS
Inactive: DH
Step 6
becQ
Step 7
becJ
Step 8Load
becK;beckB
Step 9M1
becB
+Malonyl-CoA
Step 10M2
becB
+Methylmalonyl-CoA
Step 11M3
becD
+Malonyl-CoA
Step 12M4
becD
+Malonyl-CoA
Step 13M5
becE
+Malonyl-CoA
Inactive: DH
Step 14M6
becF
+Methylmalonyl-CoA
Step 15M7
becF
+Malonyl-CoA
Step 16M8
becG
+Malonyl-CoA
Step 17TE
becG
Step 18
becO
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
129-1becALoading
Methylmalonyl-CoA
O=C(O)CC—
229-2becAM1
29-1;Malonyl-CoA
from: 29-1
CC/C=C/C(O)=O—
329-3becAM2
29-2;Malonyl-CoA
from: 29-2
CC/C=C/C=C/C(O)=O—
429-4Start—
Glycine
NCC(O)=O—
529-5becC;becI;becL;becSM3
29-3;29-4
from: 29-3, 29-4
CCC/C=C/CC(N)CC(O)=O{'Inactive': ['DH']}
629-6becQ—
29-5
from: 29-5
CCC/C=C/CC(N)CC(O)=O—
729-7becJ—
29-6
from: 29-6
CCC/C=C/CC(N)CC([R])=O—
829-8becK;beckBLoading
29-7
from: 29-7
CCC/C=C/CC(N)CC(O)=O—
929-9becBM1
29-8;Malonyl-CoA
from: 29-8
CCC/C=C/CC(N)C/C=C/C(O)=O—
1029-10becBM2
29-9;Methylmalonyl-CoA
from: 29-9
CCC/C=C/CC(N)C/C=C/C=C(C)/C(O)=O—
1129-11becDM3
29-10;Malonyl-CoA
from: 29-10
CCC/C=C/CC(N)C/C=C/C=C(C)/C=C/C(O)=O—
1229-12becDM4
29-11;Malonyl-CoA
from: 29-11
CCC/C=C/CC(N)C/C=C/C=C(C)/C=C/C=C/C(O)=O—
1329-13becEM5
29-12;Malonyl-CoA
from: 29-12
CCC/C=C/CC(N)C/C=C/C=C(C)/C=C/C=C/C(O)CC(O)=O{'Inactive': ['DH']}
1429-14becFM6
29-13;Methylmalonyl-CoA
from: 29-13
CCC/C=C/CC(N)C/C=C/C=C(C)/C=C/C=C/C(O)C/C=C(C)/C(O)=O—
1529-15becFM7
29-14;Malonyl-CoA
from: 29-14
CCC/C=C/CC(N)C/C=C/C=C(C)/C=C/C=C/C(O)C/C=C(C)/C=C/C(O)=O—
1629-16becGM8
29-15;Malonyl-CoA
from: 29-15
CCC/C=C/CC(N)C/C=C/C=C(C)/C=C/C=C/C(O)C/C=C(C)/C=C/C=C/C(O)=O—
1729-17becGTE
29-16
from: 29-16
CC1=C/C=C/CC(C/C=C/CCC)NC(/C=C/C=C/C(C)=C\CC(O)/C=C\C=C/1)=O—
1829becO—
29-17
from: 29-17
CC1=C/C=C/CC(C/C=C/CCC)NC(/C=C/C=C/C(C)=C\C(O)C(O)/C=C\C=C/1)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture