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BGC0000024PKS

Aureothin

Producing organism
Streptomyces thioluteus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
12
DOI
MIBiG entry
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aureothin
C22H23NO6397.15 Da

Gene Cluster Map9 genes · 29,132 bp

AKSATDHKRKSATDHERKRKSATKSTE5 kb29.1 kb visible · 29,132 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

12 steps · 11 edges
Step 1
Start
+Chorismic acid
Step 2
aurE
Step 3
aurG
Step 4
aurF
Step 5M1
aurA
+Methylmalonyl-CoA
Iterative
Step 6M2
aurB
+malonyl-CoA
Step 7M3
aurC
+Methylmalonyl-CoA
Iterative
Step 8M4
aurC
Module Skip
Step 9TE
aurC
Step 10
?
Step 11
aurI
Step 12
aurH
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
124-1Start—
Chorismic acid
O=C(O)C1=C[C@@H](OC(C(O)=O)=C)[C@H](O)C=C1—
224-2aurE—
24-1
from: 24-1
O=C(O)C1=C[C@@H](OC(C(O)=O)=C)[C@H](N)C=C1—
324-3aurG—
24-2
from: 24-2
O=C(O)C1=CC=C(N)C=C1—
424-4aurF—
24-3
from: 24-3
O=C(O)C1=CC=C([N+]([O-])=O)C=C1—
524-5aurAM1
24-4;Methylmalonyl-CoA
from: 24-4
CC(/C=C(C(O)=O)\C)=C\C1=CC=C([N+]([O-])=O)C=C1{'Iteration': [(['DH', 'KR']…
624-6aurBM2
24-5;malonyl-CoA
from: 24-5
CC(/C=C(CCC(O)=O)\C)=C\C1=CC=C([N+]([O-])=O)C=C1—
724-7aurCM3
24-6;Methylmalonyl-CoA
from: 24-6
CC(/C=C(CCC(O)C(C(O)C(C(O)=O)C)C)\C)=C\C1=CC=C([N+]([O-])=O)C=C1{'Iteration': [([None], 'Met…
824-8aurCM4
24-7
from: 24-7
CC(/C=C(CCC(O)C(C(O)C(C(O)=O)C)C)\C)=C\C1=CC=C([N+]([O-])=O)C=C1{'ModuleSkip': 'Skip'}
924-9aurCTE
24-8
from: 24-8
CC(/C=C(CCC(OC(C(C)=C1O)=O)=C1C)\C)=C\C2=CC=C([N+]([O-])=O)C=C2—
1024-10?—
24-9
from: 24-9
CC(/C=C(CCC(OC(O)=C1C)=C(C1=O)C)\C)=C\C2=CC=C([N+]([O-])=O)C=C2—
1124-11aurI—
24-10
from: 24-10
CC(/C=C(CCC(OC(OC)=C1C)=C(C1=O)C)\C)=C\C2=CC=C([N+]([O-])=O)C=C2—
1224aurH—
24-11
from: 24-11
CC(/C=C1CO[C@](C(OC(OC)=C2C)=C(C)C2=O)([H])C\1)=C\C3=CC=C([N+]([O-])=O)C=C3—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture