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BGC0000020PKS

Maytansine;Ansamitocin P-3

Producing organism
Actinosynnema pretiosum subsp. auranticum
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Actinosynnema
Biosynthetic class
PKS (Unknown)
Total steps
29
DOI
MIBiG entry
View on MIBiG ↗
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C34H46ClN3O10691.29 Da

Gene Cluster Map41 genes · 82,746 bp

KSKSCALKSKSKSKSKS20 kb82.7 kb visible · 82,746 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

29 steps · 28 edges
Step 1
Start
+Kanosamine
Step 5
Start
+PEP
Step 13
Start
+1,3-P2-D-glycolate
Step 2
asm22
Step 14
asm16;asm14
Step 3
?
Step 15
asm17
Step 4
?
Step 16
asm13/asm15
Step 6
?
Step 7
?
Step 8
asm23
Step 9
asm24
Step 10Load
asmA
Step 11M1
asmA
+Methylmalonyl-CoA
Step 12M2
asmA
+Malonyl-CoA
Step 17M3
asmB
Step 18M4
asmB
+Malonyl-CoA
Step 19M5
asmC
+Methylmalonyl-CoA
Step 20M6
asmD
+Methylmalonyl-CoA
Step 21M7
asmD
+Malonyl-CoA
Step 22
asm9
Step 23
asm12
Step 24
asm7
Step 25
asm21
Step 26
asm19
Step 27
asm11
Step 28
asm10
Step 29
?
+20(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions29 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
120-1Start—
Kanosamine
OC[C@H]1O[C@H](O)[C@H](O)[C@@H](N)[C@@H]1O—
220-2asm22—
20-1
from: 20-1
O[C@H]1[C@H](N)[C@@H](O)[C@@H](O)O[C@@H]1CO[R]—
320-3?—
20-2
from: 20-2
OC1(CO)C(N)C(O)C(CO[R])C1—
420-4?—
20-3
from: 20-3
O[C@]([H])([C@@]([H])(CO[R])O)C=N—
520-5Start—
PEP
C=C(C(O)=O)O[R]—
620-6?—
20-4;20-5
from: 20-4, 20-5
O[C@]([H])([C@@]([H])(CO[R])O)[C@@](N)([H])C([H])([H])C(C(O)=O)=O—
720-7?—
20-6
from: 20-6
O=C1C[C@@](O)(C(O)=O)C[C@@H](N)[C@@H]1O—
820-8asm23—
20-7
from: 20-7
C/C(C(O)=O)=C\C([C@@H](O)CN)=O—
920-9asm24—
20-8
from: 20-8
OC(C1=CC(N)=CC(O)=C1)=O—
1020-10asmALoading
20-9
from: 20-9
O=C(O)C1=CC(N)=CC(O)=C1—
1120-11asmAM1
20-10;Methylmalonyl-CoA
from: 20-10
OC1=CC(CC(C)C(O)=O)=CC(N)=C1—
1220-12asmAM2
20-11;Malonyl-CoA
from: 20-11
OC1=CC(CC(C)/C=C/C(O)=O)=CC(N)=C1—
1320-13Start—
1,3-P2-D-glycolate
[H]C(CO[R])(O)C(O[R])=O—
1420-14asm16;asm14—
20-13
from: 20-13
[H]C(CO)(O)C(O)=O—
1520-15asm17—
20-14
from: 20-14
[H]C(CO)(OC)C(O)=O—
1620-16asm13/asm15—
20-15
from: 20-15
[H]C(C(O)=O)(OC)C(O)=O—
1720-17asmBM3
20-12;20-16
from: 20-12, 20-16
OC1=CC(C/C(C)=C/C=C/C(OC)C(O)=O)=CC(N)=C1—
1820-18asmBM4
20-17;Malonyl-CoA
from: 20-17
OC1=CC(C/C(C)=C/C=C/C(OC)C(CC(O)=O)=O)=CC(N)=C1—
1920-19asmCM5
20-18;Methylmalonyl-CoA
from: 20-18
OC1=CC(C/C(C)=C/C=C/C(OC)C(CC(O)C(C)C(O)=O)=O)=CC(N)=C1—
2020-20asmDM6
20-19;Methylmalonyl-CoA
from: 20-19
OC1=CC(C/C(C)=C/C=C/C(OC)C(CC(O)C(C)/C=C(C)/C(O)=O)=O)=CC(N)=C1—
2120-21asmDM7
20-20;Malonyl-CoA
from: 20-20
OC1=CC(C/C(C)=C/C=C/C(OC)C(CC(O)C(C)/C=C(C)/C(O)CC(O)=O)=O)=CC(N)=C1—
2220-22asm9—
20-21
from: 20-21
C/C(CC1=CC(NC(C[C@H](O)/C(C)=C/[C@@H]([C@H](C2)O)C)=O)=CC(O)=C1)=C\C=C\C(OC)C2=O—
2320-23asm12—
20-22
from: 20-22
C/C(CC1=CC(NC(C[C@H](O)/C(C)=C/[C@@H]([C@H](C2)O)C)=O)=C(Cl)C(O)=C1)=C\C=C\C(OC)C2=O—
2420-24asm7—
20-23
from: 20-23
C/C(CC1=CC(NC(C[C@H](O)/C(C)=C/[C@@H]([C@H](C2)O)C)=O)=C(Cl)C(OC)=C1)=C\C=C\C(OC)C2=O—
2520-25asm21—
20-24
from: 20-24
C/C(CC1=CC(N2)=C(Cl)C(OC)=C1)=C\C=C\C(OC)[C@@](N3)(O)C[C@H](OC3=O)[C@@H](C)/C=C(C)/[C@@H](O)CC2=O—
2620-26asm19—
20-25
from: 20-25
C/C(CC1=CC(N2)=C(Cl)C(OC)=C1)=C\C=C\C(OC)[C@@](N3)(O)C[C@H](OC3=O)[C@@H](C)/C=C(C)/[C@@H](OC(C(C)C)=O)CC2=O—
2720-27asm11—
20-26
from: 20-26
C/C(CC1=CC(N2)=C(Cl)C(OC)=C1)=C\C=C\C(OC)[C@@](N3)(O)C[C@H](OC3=O)[C@@H](C)[C@@]4([H])O[C@@](C)4[C@@H](OC(C(C)C)=O)CC2=O—
2820(1)asm10—
20-27
from: 20-27
C/C(CC1=CC(N2C)=C(Cl)C(OC)=C1)=C\C=C\C(OC)[C@@](N3)(O)C[C@H](OC3=O)[C@@H](C)[C@@]4([H])O[C@@](C)4[C@@H](OC(C(C)C)=O)CC2=O—
2920(2)?—
20(1)
C/C(CC1=CC(N2C)=C(Cl)C(OC)=C1)=C\C=C\C(OC)[C@@](N3)(O)C[C@H](OC3=O)[C@@H](C)[C@@]4([H])O[C@@](C)4[C@@H](OC([C@H](C)N(C(C)=O)C)=O)CC2=O—
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