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BGC0000001PKS

abyssomicin C;atrop-abyssomicin C

Producing organism
Micromonospora maris AB-18-032
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Type I)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗
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C19H22O6346.14 Da

Gene Cluster Map29 genes · 59,320 bp

KSATKSATKSATKSKSKSATERKSAT10 kb59.3 kb visible · 59,320 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
FkFkbH-like

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1M1
abyB1
+Malonyl-CoA
Step 8
abyA2;abyA3
+1,3-BPG
Step 2M2
abyB1
+Malonyl-CoA
Step 3M3
abyB1
+Malonyl-CoA
Step 4M4
abyB1
+Malonyl-CoA
Step 5M5
abyB2
+Methylmalonyl-CoA
Inactive: DH, KR
Step 6M6
abyB2
+Methylmalonyl-CoA
Step 7M7
abyB3
+Malonyl-CoA
Step 9
abyA1?
Step 10
abyA5?
Step 11
abyA4?
Step 12
Step 13
abyE
Step 14
?
Step 15
?
+1(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11-1abyB1M1
Malonyl-CoA
OC(C)=O—
21-2abyB1M2
1-1;Malonyl-CoA
from: 1-1
OC(/C=C/C)=O—
31-3abyB1M3
1-2;Malonyl-CoA
from: 1-2
C/C=C/C=C/C(O)=O—
41-4abyB1M4
1-3;Malonyl-CoA
from: 1-3
C/C=C/C=C/C=C/C(O)=O—
51-5abyB2M5
1-4;Methylmalonyl-CoA
from: 1-4
C/C=C/C=C/C=C/C([C@H](C)C(O)=O)=O{'Inactive': ['DH', 'KR']}
61-6abyB2M6
1-5;Methylmalonyl-CoA
from: 1-5
C/C=C/C=C/C=C/C([C@H](C)C[C@H](C)C(O)=O)=O—
71-7abyB3M7
1-6;Malonyl-CoA
from: 1-6
C/C=C/C=C/C=C/C([C@H](C)C[C@H](C)C(CC(O)=O)=O)=O—
81-8abyA2;abyA3—
1,3-BPG
OC(C(O)CO)=O—
91-9abyA1?—
1-7;1-8
from: 1-7, 1-8
C/C=C/C=C/C=C/C([C@H](C)C[C@H](C)C(C(C(C(CO)O)=O)C(O)=O)=O)=O—
101-10abyA5?—
1-9
from: 1-9
C/C=C/C=C/C=C/C([C@H](C)C[C@H](C)C(C(C(O)C1CO)C(O1)=O)=O)=O—
111-11abyA4?—
1-10
from: 1-10
C/C=C/C=C/C=C/C([C@H](C)C[C@H](C)C(C(C(O)C1=C)C(O1)=O)=O)=O—
121-12—
1-11
from: 1-11
C[C@H]1C=C[C@H]2/C=C/C([C@@H](C)C[C@@H](C)C(C(C(C3)=O)=C(O)[C@@]23C1)=O)=O—
131-13abyE—
1-12
from: 1-12
C[C@H]1[C@H]2[C@H](O2)[C@H]3/C=C/C([C@@H](C)C[C@@H](C)C(C(C(C4)=O)=C(O)[C@@]34C1)=O)=O—
141(1)?—
1-13
from: 1-13
C[C@H]1[C@@H]2[C@H](O)[C@H]3/C=C/C([C@@H](C)C[C@@H](C)C(C(C(C4)=O)=C(O2)[C@@]34C1)=O)=O—
151(2)?—
1(1)
CC1C[C@]23OC(=O)C4=C2OC1C(O)C3\C=C/C(=O)[C@@H](C)C[C@@H](C)C4=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture